GentleYAG 1064nm激光治疗对小鼠皮肤屏障功能及弹性的影响

目的研究GentleYAG1064nm激光嫩肤治疗对皮肤屏障功能的影响。方法GentleYAG1064nm激光照射小鼠背部皮肤,每周1次,在激光照射前、首次照射后1周、连续3次照射后1周和连续4次照射后4周时检测皮肤经表皮失水(tramsepidermalwaterloss,TEWL)、含水量和皮肤弹性的变化。结果首次激光照射小鼠皮肤后1周时TEWL,皮肤含水量和皮肤弹性基本上较正常对照组无显著性改变(P>0.05);连续3次激光照射小鼠皮肤后1周时TEWL值和皮肤含水量仍较正常对照组无显著性改变(P>0.05),但是皮肤弹性较正常对照组有显著性改善(P<0.05);连续4次激光照射小鼠皮肤后4周时TEWL值和皮肤含水量仍较正常对照组无显著性改变(P>0.05),皮肤弹性较正常对照组有显著性改善(P<0.05),其值高于连续3次激光照射后1周时,但两者间差异无显著性(P>0.05);用动态冷却系统(dynamiccoolingdevice,DCD)组和不用DCD组的TEWL值、皮肤含水量和皮肤弹性值在各个时间点上均无显著性差异(P>0.05)。结论①单次GentleYAG1064nm激光照射小鼠皮肤对皮肤屏障功能无明显的损伤。②多次GentleYAG1064nm激光照射可以改善皮肤弹性,说明多次GentleYAG1064nm激光照射有显著的嫩肤效果。③使用DCD对激光嫩肤效果无明显的促进作用。

Influence of GentleYAG 1064 nm Laser Therapy on the Skin Barrier Function and Elasticity of Murine

Objective To study the influence of GentleYAG 1064nm laser on the skin barrier function.Methods GentleYAG 1064nm laser was used to treat murine dorsal skin once a week,and we inspected skin transepidermal water loss(TEWL) ,skin capacitance and skin elasticity on 1 week after the first laser treatment and 1 week after three laser treatments and 4 week after four laser treatments respectively.Results Skin TEWL,skin capacitance and skin elasticity had no significant changes on 1 week after the first laser treatment(P>0.05).Skin TEWL and skin capacitance still had no significant changes on 1 week after three consecutive laser treatments(P>0.05),but skin elasticity had been significantly improved(P<0.05).Skin TEWL and skin capacitance still had no significant changes on 4 week after four consecutive laser treatments(P>0.05),and skin elastricity also were significantly improved(P<0.05) ,though the value was higher than that of on 1 week after three consecutive laser treatments,there was no significant difference between them(P>0.05). Skin TEWL,skin capacitance and skin elasticity of the groups with DCD had no significant differences comparing with those of DCD groups(P>0.05).Conclusion ①Single treatment with GentleYAG 1064nm laser has no significant effect on the murine skin barrier function. ②Multiple consecutive laser treatments can obviously improve skin elasticity ,so it has rejuvenational effects. ③The dynamic cooling device is not helpful to increase the rejuvenational effects.