缬沙坦联合赖诺普利对原发性高血压患者血脂和肾功能的影响

目的 观察缬沙坦联合赖诺普利应用于原发性高血压患者治疗对其血脂和肾功能的影响。方法 选择攀枝花市中心医院于2014年1月-2015年3月收治的原发性高血压患者85例作为研究对象，按照配对分组法分为两组，对照组40例，给予赖诺普利治疗，观察组45例，给予缬沙坦联合赖诺普利治疗，均连续治疗12周，比较两组患者疗效，并测定两组患者血脂及肾功能进行统计学分析。结果 观察组总有效率为91.1%，显著高于对照组67.5%（P<0.05）。治疗12周后，观察组总胆固醇（TC）、三酰甘油（TG）、低密度脂蛋白（LDL-C）水平均显著低于对照组（P<0.05），高密度脂蛋白（HDL-C）水平显著高于对照组（P<0.05）。观察组肌酐（Cr）、血尿素氮（BUN）水平均低于对照组（P<0.05）。结论 缬沙坦联合赖诺普利治疗原发性高血压患者疗效较佳，具有较强调脂作用，并可延缓高血压所致的肾功能损害，具有重要临床价值。

Influence of Valsartan combined with Lisinopril on blood lipid and renal function in patients with primary hypertension

Objective To observe the influence of Valsartan and Lisinopril on blood lipid and renal function in patients with primary hypertension. Methods Patients (85 cases) with primary hypertension treated in Panzhihua Central Hospital in January 2014 to March 2015 were selected as research objects, then according to the paired grouping method all patients were divided into two groups. There were 40 cases in control group who were given Lisinopril treatment; 45 cases in observation group treated with combination of Valsartan and Lisinopril. Both groups were treated for 12 weeks. The efficacies of two groups were compared and blood lipid and renal function were determined and statistically analyzed. Results The total effective rate of the observation group was 91.1% and significantly higher than control group of 67.5% (P<0.05). After 12 weeks treatment, the levels of TG, LDL-C, and TC in the observation group were significantly lower than those in the control group (P<0.05), and the level of HDL-C was significantly higher than that in the control group (P<0.05). The levels of BUN and Cr in the observation group were lower than those in the control group (P<0.05). Conclusion The clinical effect of Valsartan combined with Lisinopril in primary hypertension patients is better, and it has stronger lipid regulating function and could delay impairing renal function caused by hypertension, so it has more clinical value.