金安咳喘颗粒镇咳、平喘、祛痰及抗炎作用

目的 :研究金安咳喘颗粒的药理作用。方法 :采用常规镇咳、平喘、祛痰的试验方法。结果 :金安咳喘颗粒灌胃给药能显著减少氨水致小鼠的咳嗽次数 ,增加小鼠呼吸道酚红分泌量 ,提高电刺激猫喉上神经引咳阈电压 ,延长乙酰胆碱和组胺混合液致豚鼠哮喘发作的潜伏期 ,对抗组胺及乙酰胆碱引起的豚鼠离体气管条收缩。对肺炎球菌、链球菌、消化链球菌均有较强的抑制作用 ,对二甲苯致小鼠耳肿胀及蛋清致大鼠足肿胀有明显的抑制作用。结论 :金安咳喘颗粒有镇咳、平喘、祛痰及抗菌抗炎作用。

Studies on Antitussive,Antiasthmatic,Expectorant and Anti inflammatory Effects of Jin'an Kechuan Granules

Objective:To study the pharmacologic effect of Jin'an Kechuan granules.Method:Routine antitussive,antiasthmatic and expectorant methods were used.Result:Jin'an Kechuan granules in the doses of 16,8,4 g·kg ^-1 ig could significantly decrease the frequency of cough caused by ammonia water in mice,and increase the secretion of phenol red from mouse tracheas in a dose dependent manner.The granules also help increase the threshold voltage to induce cats to cough,prolong the latent period of asthma induced by histamine and acetylcholine mixture, and antagonize the contraction of isolated trachea strips induced by histamine and acetylcholine in guinea pigs.Jin'an Kechuan granules had inhibitory effects on common bacteria in the respiratory tract as well as on the swelling of acute inflammation in mice and rats.Conclusion:Jin'an Kechuan granules have antitussive,antiasthmatic,expectorant and anti inflammatory,antibacterial effects.