The significance of the imidazole ring in anticonvulsant activity of (arylalkyl)imidazoles |
| |
Authors: | Ü nsal ali ,Sevim Dalkara,Mevlü t Ertan,Rü meysa Sunal |
| |
Affiliation: | Ünsal Çaliş,Sevim Dalkara,Mevlüt Ertan,Rümeysa Sunal |
| |
Abstract: | The imidazole ring in nafimidone [1-(2-naphthyl)-2-(1-imidazolyl)ethanone] was substituted with various groups to investigate the significance of the imidazole ring in anticonvulsant activity. For this purpose, some 2-acetylnaphthalene derivatives and their reduction products were synthesized. Several N-alkylation methods were used to prepare 2-acetylnaphthalenes. NaBH4 was used to synthesize their reduction products. Anticonvulsant activities of these compounds were determined by phase I tests of Antiepileptic Drug Development Programme. |
| |
Keywords: | |
|
|