非甾体抗炎药酮咯酸的脊髓镇痛作用

采用小鼠温浴法研究非甾体抗炎药（ＮＳＡＩＤ）酮咯酸氨了三醇的脊髓镇痛作用及其机制，发现脊髓内注射酮咯酸氨了三醇０．４ｍｇ·ｋｇ－１有明显镇痛作用，但全身给药（ｉｐ）需８ｍｇ·ｋｇ－１才能达到同样镇痛效果，脊髓与腹腔注射有效剂量比为１：２０，证实酮咯酸具有脊髓镇痛作用，该作用可被ｓｃ利血平、呱唑嗪或育亨宾取消，表明酮咯酸脊髓镇痛作用机制与内源镇痛系统中的去甲肾上腺素能神经有密切关系。本文研究结果为了解ＮＳＡＩＤｓ的中枢镇痛作用及其机制提供了新资料。

Noradrenergic mediation of spinal analgesia of ketorolac tromethamine, a NSAID

The spinal analgesic effect and its mechanism of ketorolac tromethamine(KT)were examined on the tail immersion test in mice.Dose-dependent analgesia (increased tail curl responce latency)was observed following intrathecal administration of KT 0.4 or 0.8 mg·kg-1,the ratio of effective doses for intrathecal/systemic(ip)KT was 1:20.The analgesia of intrathecal KT 0.4 mg·kg-1 was obliterated when the animals were pretreated with reserpine(3 mg·kg-1,ip),α1 receptor antagonist prazosin(10mg·kg-1,sc)or α2 receptor antagonist yohinbine(4mg·kg-1,sc).The results demonstrate that KT has the noradrenergic nerve mediated spinal analgesia and suggest that other NSAIDs might have tile same pharmacological characterization because KT is a NSAID.