| 雷公藤多甙预防大鼠肾病的体视学研究 |
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| 引用本文： | 赵军宁 王晓东. 雷公藤多甙预防大鼠肾病的体视学研究[J]. 中国药理学通报, 1995, 11(6): 468-472 |
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| 作者姓名： | 赵军宁 王晓东 |
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| 作者单位： | 四川省中药研究所药理研究室 |
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| 摘 要： | 应用新近发展起来的体视学方法和计算机图像分析系统，在光镜和电镜水平，同时结合功能观察，定量研究了雷公藤多甙对阿霉素所致肾病大鼠肾小球三维空间构筑和多聚阴离子含量的影响。结果表明，雷公藤多甙对病鼠肾脏滤过屏障机械通透性能的降低并无明显改善作用，其治疗肾病蛋白尿的机理主要是通过保护或修复肾小球电荷屏障来实现的。
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| 关 键 词： | 雷公藤多甙；肾病综合征；体视学；图像分析系统；大鼠；肾小球 |
Stereological study on protection of poliglycosides of triptrtygium wilfordii(GTW)against adrimycin-induced nephrotic syndrome in rats |
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| ZHAO Jun-Ning,WANG Xiao-Dong,PENG Nong-Ling,WEN Zhi-jian. Stereological study on protection of poliglycosides of triptrtygium wilfordii(GTW)against adrimycin-induced nephrotic syndrome in rats[J]. Chinese Pharmacological Bulletin, 1995, 11(6): 468-472 |
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| Authors: | ZHAO Jun-Ning WANG Xiao-Dong PENG Nong-Ling WEN Zhi-jian |
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| Abstract: | The stereological methods and computer image analysis system,combined light and electron microscope,were applied to estimate three dimensional structure and amount of polyanion of the glomerulus.It is concluded that protection of GTW against nephrosis might mainly be associated with the repair of anion ultrafiltration barrier. |
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| Keywords: | poliglycosides of triptrtygium wilfordii nephrotic syndrome stereology image analyser rat glomerulus |
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