| 金丝桃甙对心肌脂质过氧化的影响 |
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| 引用本文： | 汪为群 方志炼. 金丝桃甙对心肌脂质过氧化的影响[J]. 中国药理学通报, 1995, 11(2): 123-125 |
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| 作者姓名： | 汪为群 方志炼 |
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| 作者单位： | 安徽医科大学药理教研室，安徽屯溪第二制药厂 |
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| 摘 要： | 用ＴＢＡ法测定丙二醛（ＭＤＡ）含量，观察金丝桃甙（Ｈｙｐ）对阿霉素以及缺氧／再灌注所致心肌脂质过氧化的影响。结果表明：Ｈｙｇ１００ｍｇ·ｋｇ－１和ＥＧＴＡ４００μｍｏｌ·ｋｇ－１ｉｐ可明显抑制阿霉素所致小鼠心肌ＭＤＡ含量的升高，ＨＰＰ可增强ＥＧＴＡ的作用，Ａ２３１８７拮抗Ｈｙｐ的作用。ＨｙＰ１０、１００μｍｏｌ·Ｌ－１可显著减少缺氧；再灌注离体大鼠心脏ＭＤＡ的产生。提示Ｈｙｐ具有抗心肌脂质过氧化的作用，此作用可能与其阻滞钙内流有关。
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| 关 键 词： | 金丝桃甙；脂质过氧化；丙二醛；阿霉素；心肌缺氧与再灌注 |
Effect of hyperin on myocardial lipid peroxidation |
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| WANG Wei-Qun,ZHANG Yan,FANG Zhi-Lian, et al. Effect of hyperin on myocardial lipid peroxidation[J]. Chinese Pharmacological Bulletin, 1995, 11(2): 123-125 |
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| Authors: | WANG Wei-Qun ZHANG Yan FANG Zhi-Lian et al |
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| Abstract: | The effect of hyperin(Hyp) on adriamycin-and hypoxia/ reperfusion-induced myocardial lipid peroxidation was investigated using malondialdehyde (MDA) as an index. The increase in MDA in murine cardiac tissue after administration of adriamycun (15 mg·kg-1, ip) was significantly inhibited by Hyp 100 mg·kg-1 and EGTA 400 μmol·kg-1 ip. A23187 antagonized the effect of Hyp. Hyp enhanced the effect of EGTA. Also, Hyp 10, 100μmol· L-1 markedly reduced the increase in MDA production in isolated rat hearts after hypoxia/ reperfusion. The results suggest that Hyp possess an antiperoxidative activity, and this effect may be related to blocking calcium influx.(Now in Anhui Tunxi Second Pharmaceutical Factory,Huangshan 245011) |
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| Keywords: | hyperin lipid peroxidation malondialdehyde adriamycin myocardial reperfusion injury |
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