| 妊娠期高血压疾病妊娠相关蛋白A与胎盘病理改变的关系 |
| |
| 引用本文： | 陈宏霞,曹伍兰.妊娠期高血压疾病妊娠相关蛋白A与胎盘病理改变的关系[J].中国实用妇科与产科杂志,2011(1). |
| |
| 作者姓名： | 陈宏霞 曹伍兰 |
| |
| 作者单位： | 中山大学附属中山市人民医院妇产科; |
| |
| 摘 要： | 目的探讨妊娠中期妊娠相关蛋白A(PAPP-A)在预测妊娠期高血压疾病中的作用及其与胎盘病理改变的关系。方法 2008年1月至2009年12月在中山大学附属中山市人民医院对妊娠12~16周产科门诊建册并规律产检的正常单胎孕妇2025例进行研究,首次就诊时抽取肘静脉血,应用酶联免疫法检测其血清中的PAPP-A,并追踪这些孕妇的妊娠发展及分娩情况。对于发生妊娠期高血压疾病、早发型子痫前期和晚发型子痫前期者产时收集其胎盘组织,用HE染色后观察胎盘绒毛滋养细胞、合体滋养细胞结节增生情况及绒毛间质纤维化和绒毛血管病变情况。并随机抽取正常孕妇胎盘组织进行病理检查对比。结果纳入研究的孕妇2025例,剔除不符合要求病例后,共1862例孕妇中,妊娠期高血压疾病88例,需34周前终止妊娠的早发型子痫前期34例,34周后终止妊娠的晚发型子痫前期53例,正常孕妇1687例。早发型子痫前期组外周血PAPP-A水平比对照组低,P<0.05;妊娠期高血压疾病组、晚发型子痫前期组血清PAPP-A与对照组比较差异无统计学意义(P>0.05)。妊娠期高血压疾病组、早发型子痫前期组及晚发型子痫前期组胎盘病理改变率与对照组比较,总病理改变率3组与对照...
|
| 关 键 词： | 妊娠期高血压疾病 胎盘 病理 妊娠相关蛋白 子痫前期 |
The correlation of the placental pathological change and the serum PAPP-A in pregnancy with hypertensive diorders at 12~16 weeks. |
| |
| CHEN Hong-xia,CAO Wu-lan.The correlation of the placental pathological change and the serum PAPP-A in pregnancy with hypertensive diorders at 12~16 weeks.[J].Chinese Journal of Practical Gynecology and Obstetrics,2011(1). |
| |
| Authors: | CHEN Hong-xia CAO Wu-lan |
| |
| Institution: | CHEN Hong-xia,CAO Wu-lan. Department of Gynecology and Obstetrics,Zhongshan Hospital,Sun Yat-sen University,Zhongshan 528403,China |
| |
| Abstract: | Objective To investigate the predictional value of the serum PAPP-A at 12~16 weeks in hypertensive disorders in pregnancy and the relationship between the placental pathological change of hypertensive diorders in pregnancy and the serum PAPP-A at 12~16 weeks.Methods From January of 2008 to December of 2009,2025 singleton pregnancies in the Zhongshan Hospital,Sun Yat-Sen University who came for rutine prenatal care at 12~16 weeks and visit us regular later were invoved in this study.The serum PAPP-A at 12~16... |
| |
| Keywords: | hypertensive diorders in pregnancy placenta pathology PAPP-A pre-eclampsia |
| 本文献已被 CNKI 等数据库收录！ |
|
