Inflammatory bowel disease: review from the aspect of genetics |
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Authors: | Shunji Ishihara M M Aziz Takafumi Yuki Hideaki Kazumori Yoshikazu Kinoshita |
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Institution: | (1) Department of Internal Medicine II, Faculty of Medicine, Shimane University School of Medicine, 89-1, Enya-cho, Izumo, Shimane, Japan |
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Abstract: | Regardless of how inflammatory bowel disease (IBD) is defined, the term “genetic susceptibility” is always included. Due to
substantial progress in the characterization of susceptible genes that interact with environmental influences, a number of
review articles offering the latest insights continue to be presented. To date, more than 30 novel IBD susceptible loci have
been found, while several promising associations between IBD and gene variants have also been identified and replicated effectively.
The present review highlights recent insights regarding linkage analysis and genome-wide association presented in studies
of IBD susceptible genes, which provide additional evidence supporting their involvement in disease pathogenesis, based on
linking to innate immune systems as a result of interactions with intestinal microbial flora. An improved understanding of
IBD genetics will promote the identification of novel therapeutic agents, making it possible to identify environmental factors
related to intestinal inflammation. |
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