| 丁基苯酞加强造血干细胞移植及内源性干细胞动员治疗脑梗死的效应 |
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| 引用本文： | 卢宝全,尚小明,李永秋,马洪颖,刘春芹,李建珉,姚绍鑫,张瑛琪. 丁基苯酞加强造血干细胞移植及内源性干细胞动员治疗脑梗死的效应[J]. 中国神经再生研究, 2011, 6(7): 494-499 |
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| 作者姓名： | 卢宝全 尚小明 李永秋 马洪颖 刘春芹 李建珉 姚绍鑫 张瑛琪 |
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| 作者单位： | 唐山市工人医院神经内科,河北医科大学附属唐山工人医院心内科,河北医科大学附属唐山工人医院神经内科,河北医科大学附属唐山工人医院神经内科,河北医科大学附属唐山工人医院神经内科,河北联合大学附属医院神经外科,河北医科大学附属唐山工人医院放射科,河北医科大学附属唐山工人医院感染科 |
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| 基金项目： | 2009年河北省科技支撑计划课题（09276101D-10） |
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| 摘 要： | Exogenous stem cell transplantation and endogenous stem cell mobilization are both effective for the treatment of acute cerebral infarction. The compound dl-3-butylphthalide is known to improve microcirculation and help brain cells at the infarct loci. This experiment aimed to investigate the effects of dl-3-butylphthalide intervention based on the transplantation of hematopoietic stem cells and mobilization of endogenous stem cells in a rat model of cerebral infarction, following middle cerebral artery occlusion. Results showed that neurological function was greatly improved and infarct volume was reduced in rats with cerebral infarction. Data also showed that dl-3-butylphthalide can promote hematopoietic stem cells to transform into vascular endothelial cells and neuronal-like cells, and also enhance the therapeutic effect on cerebral infarction by hematopoietic stem cell transplantation and endogenous stem cell mobilization.
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| 关 键 词： | dl-3-butylphthalide hematopoietic stem cells endogenous stem cells infarction stem cell mobilization neural regeneration |
Dl-3-butylphthalide-enhanced hematopoietic stem cell transplantation and endogenous stem cell mobilization for the treatment of cerebral infarcts |
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| Baoquan Lu,Xiaoming Shang,Yongqiu Li,Hongying Ma,Chunqin Liu,Jianmin Li,Yingqi Zhang,Shaoxin Yao. Dl-3-butylphthalide-enhanced hematopoietic stem cell transplantation and endogenous stem cell mobilization for the treatment of cerebral infarcts[J]. Neural Regeneration Research, 2011, 6(7): 494-499 |
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| Authors: | Baoquan Lu Xiaoming Shang Yongqiu Li Hongying Ma Chunqin Liu Jianmin Li Yingqi Zhang Shaoxin Yao |
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| Affiliation: | 1Department of Neurology, Tangshan Workers’ Hospital, Hebei Medical University, Tangshan 063000, Hebei Province, China 2Department of Cardiology, Tangshan Workers’ Hospital, Hebei Medical University, Tangshan 063000, Hebei Province, China 3Department of Neurosurgery, Affiliated Hospital of Hebei United University, Tangshan 063000, Hebei Province, China 4Department of Infectious Diseases, Tangshan Workers’ Hospital, Hebei Medical University, Tangshan 063000, Hebei Province, China 5Department of Radiology, Tangshan Workers’ Hospital, Hebei Medical University, Tangshan 063000, Hebei Province, China |
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| Abstract: | Exogenous stem cell transplantation and endogenous stem cell mobilization are both effective for the treatment of acute cerebral infarction. The compound dl-3-butylphthalide is known to improve microcirculation and help brain cells at the infarct loci. This experiment aimed to investigate the effects of dl-3-butylphthalide intervention based on the transplantation of hematopoietic stem cells and mobilization of endogenous stem cells in a rat model of cerebral infarction, following middle cerebral artery occlusion. Results showed that neurological function was greatly improved and infarct volume was reduced in rats with cerebral infarction. Data also showed that dl-3-butylphthalide can promote hematopoietic stem cells to transform into vascular endothelial cells and neuronal-like cells, and also enhance the therapeutic effect on cerebral infarction by hematopoietic stem cell transplantation and endogenous stem cell mobilization. |
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| Keywords: | dl-3-butylphthalide hematopoietic stem cells endogenous stem cells infarction stem cell mobilization neural regeneration |
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