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Citrus auraptene suppresses cyclin D1 and significantly delays N-methyl nitrosourea induced mammary carcinogenesis in female Sprague-Dawley rats |
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| Authors: | Prasad Krishnan Karen J Yan David Windler Jesse Tubbs Robert Grand Benjamin DL Li C Marcelo Aldaz Jerry McLarty Heather E Kleiner-Hancock |
| Affiliation: | (1) Department of Pharmacology, Toxicology and Neuroscience, LSUHSC-Shreveport, Louisiana, USA;(2) Breast Cancer Focus Group, Feist-Weiller Cancer Center, Louisiana, Shreveport, USA;(3) Department of Surgical Oncology, LSUHSC-Shreveport, Louisiana, USA;(4) Department of Carcinogenesis, U.T.M.D. Anderson Cancer Center, Smithville, Texas, USA;(5) Department of Medicine, LSUHSC-Shreveport, Louisiana, USA |
| Abstract: | BackgroundBreast cancer is a major problem in the United States leading to tens of thousands of deaths each year. Although citrus auraptene suppresses cancer in numerous rodent models, its role in breast cancer prevention previously has not been reported. Thus, our goal was to determine the anticarcinogenic effects of auraptene against breast cancer. |
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