Microbial community analysis reveals high level phylogenetic alterations in the overall gastrointestinal microbiota of diarrhoea-predominant irritable bowel syndrome sufferers |
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| Authors: | Lotta Krogius-Kurikka Anna Lyra Erja Malinen Johannes Aarnikunnas Jarno Tuimala Lars Paulin Harri M?kivuokko Kajsa Kajander Airi Palva |
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| Affiliation: | (1) Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, University of Helsinki, PO Box 66, FI-00014 Helsinki, Finland;(2) CSC - Scientific Computing Ltd, Espoo, Finland;(3) DNA Sequencing Laboratory, Institute of Biotechnology, University of Helsinki, Helsinki, Finland;(4) Danisco Innovation, Kantvik, Finland;(5) Valio Ltd, Research Centre, Helsinki, Finland;(6) Department of Biomedicine, Faculty of Medicine, University of Helsinki, Helsinki, Finland;(7) The Finnish Red Cross, Blood Service, Helsinki, Finland |
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| Abstract: | Background A growing amount of scientific evidence suggests that microbes are involved in the aetiology of irritable bowel syndrome (IBS), and the gastrointestinal (GI) microbiota of individuals suffering from diarrhoea-predominant IBS (IBS-D) is distinguishable from other IBS-subtypes. In our study, the GI microbiota of IBS-D patients was evaluated and compared with healthy controls (HC) by using a high-resolution sequencing method. The method allowed microbial community analysis on all levels of microbial genomic guanine plus cytosine (G+C) content, including high G+C bacteria. |
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