A microprocessor-controlled tracheal insufflation-assisted total liquid ventilation system |
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| Authors: | James Courtney Parker Adel Sakla Francis M. Donovan David Beam Annu Chekuri Mohammad Al-Khatib Charles R. Hamm Fabien G. Eyal |
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| Affiliation: | (1) Department of Physiology, University of South Alabama, MSB 3074, Mobile, AL 36688, USA;(2) Department of Pediatrics, University of South Alabama, Mobile, AL 36688, USA;(3) Department of Mechanical Engineering, University of South Alabama, Mobile, AL 36688, USA;(4) Department of Electrical and Computer Engineering, University of South Alabama, Mobile, AL 36688, USA |
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| Abstract: | A prototype time cycled, constant volume, closed circuit perfluorocarbon (PFC) total liquid ventilator system is described. The system utilizes microcontroller-driven display and master control boards, gear motor pumps, and three-way solenoid valves to direct flow. A constant tidal volume and functional residual capacity (FRC) are maintained with feedback control using end-expiratory and end-inspiratory stop-flow pressures. The system can also provide a unique continuous perfusion (bias flow, tracheal insufflation) through one lumen of a double-lumen endotracheal catheter to increase washout of dead space liquid. FRC and arterial blood gases were maintained during ventilation with Rimar 101 PFC over 2–3 h in normal piglets and piglets with simulated pulmonary edema induced by instillation of albumin solution. Addition of tracheal insufflation flow significantly improved the blood gases and enhanced clearance of instilled albumin solution during simulated edema. |
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