| 维甲酸在诱导再分化治疗分化型甲状腺癌中的价值 |
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| 引用本文： | 叶智轶,王辉,吴靖川. 维甲酸在诱导再分化治疗分化型甲状腺癌中的价值[J]. 国际放射医学核医学杂志, 2007, 31(4): 221-225 |
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| 作者姓名： | 叶智轶 王辉 吴靖川 |
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| 作者单位： | 200092 上海, 上海交通大学医学院附属新华医院核医学科 |
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| 摘 要： | 分化型甲状腺癌约有30%肿瘤发生去分化,以致于术后131I治疗和甲状腺素替代治疗疗效差或无效。维甲酸作为维生素A的生物活性代谢产物,对于多种细胞的发生、增殖、分化起着重要的作用。多项研究发现,维甲酸诱导再分化治疗分化型甲状腺癌的潜力巨大。
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| 关 键 词： | 分化型甲状腺癌 维甲酸 再分化 |
| 文章编号： | 1673-4114（2007）04-221-05 |
| 收稿时间： | 2006-12-24 |
| 修稿时间： | 2006-12-24 |
The value of retinoic acid-induced redifferentiation in the treatment of differentiated thyroid carcinoma |
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| YE Zhi-yi,WANG Hui,WU Jing-chuan. The value of retinoic acid-induced redifferentiation in the treatment of differentiated thyroid carcinoma[J]. International Journal of Radiation Medicine and Nuclear Medicine, 2007, 31(4): 221-225 |
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| Authors: | YE Zhi-yi WANG Hui WU Jing-chuan |
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| Affiliation: | Department of Noclear Medicine, Xinhua Hospilal, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China |
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| Abstract: | About 30% of differentiated thyroid carcinoma(DTC) loses its ability of differentiation, which results in poor or no effect of the radioiodine therapy and the thyroid hormone replacement therapy after operation. Retinoic acids, the biologically active metabolite of vitamin A, is of central importance for growth, proliferation and differentiation of various cells. In this review, summarized the mechanism of the dedifferentiation among the DTC, the retinoic acids-induced redifferention and the clinical use of retinoic acids. It is demonstrated by many studies that retinoic acids-induced redifferentiaon has a large potential in the treatment of DTC. |
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| Keywords: | Differentiated thyroid carcinoma Retinoic acids Redifferentiation |
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