同种异体肢体移植的研究

目前先天性畸形,创伤性截肢及肿瘤切除术后所致的肢体缺损,仍只能用假肢替代,而假肢不具有生物功能。肢体移植的方法如能较成熟地应用于临床,无疑是肢体重建的最佳选择。由于各种强有力的免疫抑制剂的发现及应用、显微外科技术的发展,使同种异体肢体移植成为现实,现已展示了广阔的前景。本文从组织配型、冷冻保存、免疫抑制、基因治疗、组织工程等方面对肢体移植的研究进展简要综述。

The Progress of Homologous Limb Allograft

Nowadays the absent extremities after congenital deformity,traumatic amputation and bone tumor resection can be reconstructed by artificial extremities.However,the artificial extremities have no biologic capability.If the method of limb allograft can be applied in clinic maturely,limb reconstruction maybe the best choice undoubtedly.With the discovery and application of various drastic immunsuppressive agent and the development of microsurgical technique,limb allograft has become reality and displayed extensive perspective.This article reviews the research progress of limb allograft briefly from tissue matching,cryopreservation,immune suppression,gene therapy,tissue engineering and so on.