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溃疡康对胃溃疡小鼠胃粘膜保护作用的实验研究
引用本文:刘立伟,高慧英,王振军,王新成,宋炎峰,姜信诚. 溃疡康对胃溃疡小鼠胃粘膜保护作用的实验研究[J]. 泰山医学院学报, 2004, 25(5): 418-420
作者姓名:刘立伟  高慧英  王振军  王新成  宋炎峰  姜信诚
作者单位:1. 兰州医学院,甘肃,兰州,730000
2. 泰山医学院,山东,泰安,271000
摘    要:目的观察溃疡康对不同实验性胃溃疡模型的作用。方法采用束缚水浸、乙醇、利血平诱导致小鼠急性胃粘膜损伤,以溃疡指数及胃粘膜组织学改变为指标,观察溃疡康对不同实验性胃溃疡小鼠胃粘膜损伤的影响。结果不同类型急性胃粘膜损伤小鼠溃疡康预防组溃疡指数均较小,镜检胃粘膜损伤较轻。结论溃疡康对束缚应激法和乙醇致小鼠胃溃疡均有明显的抑制作用。

关 键 词:小鼠 实验性胃溃疡 急性胃粘膜损伤 胃粘膜保护作用 观察 实验研究 束缚应激 指数 乙醇 结论
文章编号:1004-7115(2004)05-0418-03
修稿时间:2004-05-24

The Inhibitory effects of the Kui Yang Kang in experimental gastric ulcer on mice
LIU Li-wei,GAO Hui-ying,WANG Zhen-jun,WANG Xin-cheng,SONG Yan-feng,JIANG Xin-cheng. The Inhibitory effects of the Kui Yang Kang in experimental gastric ulcer on mice[J]. Journal of Taishan Medical College, 2004, 25(5): 418-420
Authors:LIU Li-wei  GAO Hui-ying  WANG Zhen-jun  WANG Xin-cheng  SONG Yan-feng  JIANG Xin-cheng
Abstract:Objective: To observe the effects of the Traditional Chinese Medical herbs Kui Yang Kang (KYK) in experimental gastric ulcer on mice. Method : Three kinds of mice ulcer models induced by binding and water immersion-restraint stress(WRS), alcohol and reserpine respectively ;the extent of gastric mucosal injury was evaluated grossly and histologically. Results: The index of ulcer of each KYK pretreated group decreased in number and pathologic changes of gastric mucosa are less severe. Conclusion: The results show that the Kui Yang Kang could be significantly in antagnisim to experimental ulcers on mice induced by WRS and alcohol respectively.
Keywords:Kui Yang Kang  gastric ulcer  index of ulcer  histology  mice
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