The impact of P53 and P21(waf1) expression on the survival of patients with the germinal center phenotype of diffuse large B-cell lymphoma |
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Authors: | Visco Carlo Canal Fabio Parolini Claudia Andreoli Annalisa Ambrosetti Achille Krampera Mauro Lestani Maurizio Pizzolo Giovanni Chilosi Marco |
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Institution: | Department of Hematology, Ospedale S. Bortolo, Vicenza, Italy. carlovisco@hotmail.com |
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Abstract: | Immunohistochemically detected over-expression of P53-related protein (P53+++) and absence of P21(waf1) expression (P21-) correspond to loss of function of the P53-gene in diffuse large B-cell lymphoma (DLBCL) patients. Using immunohistochemistry we examined 80 patients with DLBCL and found that 23% had the P53+++/P21- phenotype while 51% had a germinal center (GC) pattern. Both the P53+++/P21- phenotype and the non-GC pattern were associated with inferior outcome. Notably, the prognostic power of the P53+++/P21- phenotype was restricted to patients with a GC pattern, without effect on outcome of patients with a non-GC phenotype. Our results show that immunohistochemistry can parallel gene expression profiling in addressing clinical variability of DLBCL patients. |
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