| 三乙醇胺复合物促进氟比洛芬体外经皮透过 |
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| 引用本文： | 冯彩霞,徐晖,王绍宁,唐星,郑俊民. 三乙醇胺复合物促进氟比洛芬体外经皮透过[J]. 沈阳药科大学学报, 2008, 25(4): 255-257 |
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| 作者姓名： | 冯彩霞 徐晖 王绍宁 唐星 郑俊民 |
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| 作者单位： | 沈阳药科大学药学院,辽宁沈阳,110016 |
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| 摘 要： | 目的合成氟比洛芬三乙醇胺复合物(Flu-TEA),考察氟比洛芬(Flu)及Flu-TEA的体外经皮透过性。方法采用双室水平扩散池,大鼠腹部全皮为渗透膜,分别以增塑剂柠檬酸三乙酯或经皮穿透促进剂为溶剂,测定药物的体外经皮透过性。结果Flu-TEA的体外经皮透过系数均高于Flu,氮酮、肉豆蔻酸异丙酯(IPM)、1,2-丙二醇3种经皮穿透促进剂中,氮酮与1,2-丙二醇联用对药物的促透效果最佳。结论Flu与三乙醇胺成复合物盐后可明显增加体外经皮透过性。
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| 关 键 词： | 经皮透过 氟比洛芬 三乙醇胺 穿透促渗剂 |
| 文章编号： | 1006-2858(2008)04-0255-03 |
| 收稿时间： | 2007-05-09 |
| 修稿时间： | 2007-05-09 |
Improvement of transdermal permeation of flurbiprofen via complex salts formation with triethanolamine |
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| FENG Cai-xia,XU Hui,WANG Shao-ning,TANG Xing,ZHENG Jun-min. Improvement of transdermal permeation of flurbiprofen via complex salts formation with triethanolamine[J]. Journal of Shenyang Pharmaceutical University, 2008, 25(4): 255-257 |
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| Authors: | FENG Cai-xia XU Hui WANG Shao-ning TANG Xing ZHENG Jun-min |
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| Affiliation: | School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016 |
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| Abstract: | Objective To synthesis flurbiprofen triethanolamine salt (Flu-TEA), and study the in vitro transdermal permeation properties of flurbiprofen (Flu) and Flu-TEA. Methods Drug permeability through excised full skin of rats was determined by using side-by-side diffusion cells device, and plasticizer (triethyl citrate) or permeation enhancers as solvents. Results Flu-TEA possessed obviously higher transdermal permeation rate than Flu, and azone combined with propylene glycol provided the highest penetration enhancing ability for both Flu and Flu-TEA. Conclusions The transdermal permeability of Flu can be effectively improved through salt-formation of flurbiprofen with triethanolamines. |
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| Keywords: | transdermal permeation flurbiprofen triethanolamine permeation enhancer |
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