| Effects of methylation status of caspase-8 promoter on antitumor activity of TRAIL to human gastric cancer cells |
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| 引用本文： | 张汝刚 房殿春 杨柳芹 罗元辉. Effects of methylation status of caspase-8 promoter on antitumor activity of TRAIL to human gastric cancer cells[J]. 中国人民解放军军医大学学报, 2004, 19(3): 139-141,145 |
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| 作者姓名： | 张汝刚 房殿春 杨柳芹 罗元辉 |
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| 作者单位： | GastroenterologyResearchCenter,SouthwestHospital,ThirdMilitaryMedicalUniversity,Chongqing400038,China |
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| 基金项目： | SupportedbytheNationalNaturalScienceFoundationofChina (0 1MA172) |
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| 摘 要： | To study the effects of the methylation status of caspuse-8 promoter on the antitunlor activity of TRAIL to the human gastric cancer cells. Methods: The methylation of caspuse-8 was measured with methylation specific PCR (MSP) and the antitomor capability of TRAIL to human gastric cancer cells was determined with MTT. Results: No methylation of caspase-8 in the human gastric cancer cells was found. The sensitivity of 5 lines of gastric cancer cells to the antitumor activity of TRAIL was different. The administration of the demethylation agent 5-Aza-2‘-deoxycytidine (5-Aza-CdR) increased the sensitivity of gastric cancer cells to TRAIL but did not change the methylation status of caspuse-8 promoter in gastric cancer cells. Conclusion: 5-Aza-CdR increases the sensitivity of most of gastric cancer cells to TRAIL butcaspuse-8 is not involved in the antitumor activity of TRAIL.
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| 关 键 词： | 抗菌素 活动性 TRAIL 胃癌 癌细胞 甲基化作用 MSP 肿瘤 |
Effects of methylation status of caspase-8 promoter on antitumor activity of TRAIL to human gastric cancer cells |
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| ZHANG Ru-gang,FANG Dian-chun,YANG Liu-qin,LUO Yuan-gang Gastroenterology Research Center,Southwest Hospital,Third Military Medical University,Chongqing ,China. Effects of methylation status of caspase-8 promoter on antitumor activity of TRAIL to human gastric cancer cells[J]. Journal of Medical Colleges of PLA(China), 2004, 19(3): 139-141,145 |
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| Authors: | ZHANG Ru-gang FANG Dian-chun YANG Liu-qin LUO Yuan-gang Gastroenterology Research Center Southwest Hospital Third Military Medical University Chongqing China |
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| Affiliation: | ZHANG Ru-gang,FANG Dian-chun,YANG Liu-qin,LUO Yuan-gang Gastroenterology Research Center,Southwest Hospital,Third Military Medical University,Chongqing 400038,China |
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| Abstract: | |
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| Keywords: | Aza-CdR TRAIL caspase-8 methylation gastric carcinoma |
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