DCE-MRI在颈动脉粥样硬化斑块新生血管定量测量中的应用

目的 采用磁共振动态增强扫描(DCE-MRI)测量颈动脉粥样硬化斑块各成分容积传输常数(K^trans)评估新生血管,为定量测量新生血管及评估斑块稳定性提供依据。方法 颈动脉粥样硬化斑块患者均行MRI平扫及DCE-MRI扫描,根据各成分信号分为纤维组织组、钙化组、近期出血组和脂质核心组,后处理软件评估各组K^trans值。结果 各组之间有不同的K^trans值,纤维组织组拥有较高的K^trans值(0.591/min)、钙化组(0.031/min)、近期出血组(0.115/min)和脂质核心组(0.048/min)拥有较低的K^trans值。各组之间K^trans值两两比较,近期出血组和脂质核心组差异无统计学意义(P>0.05),纤维组织组与钙化组、纤维组织组与近期出血组、纤维组织组与脂质核心组、钙化组与近期出血组、钙化组与脂质核心组之间差异有统计学意义(P<0.05)。结论 K^trans值反映各组渗透性和新生血管含量的不同,可作为定量评估斑块新生血管、评估斑块稳定性的重要依据。

Application of DCE-MRI in the quantitative measurement of neovascularization in carotid atherosclerotic plaque

Objective To evaluate neovascularization by measuring the volume transfer constant (K^trans) of the different components in carotid atherosclerosis plaques after DCE-MRI dynamic contrast-enhanced magnetic resonance imaging, in order to provide evidence to determine plaque stability and quantitative measurement of neovascularization. Methods A total of 41 patients with suspected atherosclerotic plaques in carotid arteries were scanned with MRI and DCE-MRI, and then divided into different groups according to each component signal:fibrosis group, calcification group, recent hemorrhage group and lipid core group. Data of dynamic enhancement were treated with a post processing procedure to evaluate and compare the volume transfer constant (K^trans) of various components in the plaques. Results There were different K^trans values in different groups:0.591/min in fibrosis group, 0.031/min in calcification group, 0.115/min in recent hemorrhage group, and 0.048/min in lipid core group. There was no difference between the lipid core and recent hemorrhage groups (P>0.05), but there were differences between the other groups (P<0.05). Conclusion K^trans value in different components can reflect the different permeability and blood supply. It can be used as an indicator to assess the plaque stability and neovascularization.