Single nucleotide polymorphisms of the APC gene and colorectal cancer risk: a case-control study in Taiwan |
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| Authors: | Shee-Ping Chen Shih-Tzu Tsai Shu-Wen Jao Yen-Lun Huang Yu-Chen Chao Yi-Lin Chen Chang-Chieh Wu Shinn-Zong Lin Horng-Jyh Harn |
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| Affiliation: | (1) Institute of Medical Sciences, Buddhist Tzu Chi University, 703, Section 3, Chung-Yang Road, 970 Hualien, Taiwan;(2) Neuro-Medical Scientific Center Departments, Buddhist Tzu Chi General Hospital, Hualien, Taiwan;(3) Department of Family Medicine, Buddhist Tzu Chi General Hospital, Hualien, Taiwan;(4) Department of Surgery, Tri-Service General Hospital, Taipei, Taiwan;(5) Department of pathology, Buddhist Tzu Chi General Hospital, Hualien, Taiwan |
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| Abstract: | Background Colorectal cancer (CRC), which has become especially prevalent in developed countries, is currently the third highest cause of cancer mortality in Taiwan. Mutation of the adenomatous polyposis coli (APC) gene, a tumour suppressor, is thought to be an early event in colorectal tumourigenesis. To date, however, no large-scale screening for APC gene variants in Chinese subjects has been performed. The present study was undertaken to identify APC gene variants that are significantly associated with the occurrence of CRC in Taiwanese subjects. |
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