New evidence for detecting Helicobacter pylori in clinics

A part of diagnostic tests for Helicobacter pylori was approved as National Health Insurance system in Ministry of Health and Welfare Japan on last November 2000. The gold standard for the presence of most infectious diseases is successful culture of the organism. H. pylori is fastidious and time consuming for growth in media. Instead of bacterial culture of H. pylori from biopsy sample, we need to effort to develop rapid methods to identify gene segment of H. pylori and its antibiotic resistance. Even the genetic methods would be developed, circular antigen product of H. pylori must be important for diagnosis of its clinical pathology. Here we listed the available diagnostic tests for histology, bacterial culture, rapid urease test, urea breath testing, and serological testing for H. pylori in Japan.