绝经后妇女冠心病患者性激素水平与脂质代谢的临床观察

目的:观察绝经后妇女冠心病(CHD)患者血清性激素水平与脂质代谢关系。方法:58例绝经后妇女CHD患者作为观察组,58例绝经后健康妇女作为对照组,测定两组性激素相关指标(血清雌二醇(E2)、孕酮(P)、睾酮(T)、催乳素(PRL)、黄体生成素(LH)、促卵泡激素(FSH)、E/T)及脂质代谢相关指标(总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白B(ApoB)、HDL-C/LDL-C、HDL-C/TC)水平,并进行相关性分析。结果:观察组患者E2、HDL-C、E/T、HDL-C/LDL-C、HDL-C/TC水平明显低于对照组,TC、TG、LDL-C、ApoB水平均明显高于对照组,差异有统计学意义(P<0.01或P<0.05);经多元回归分析观察组患者E2、E/T与TC、TG、LDL-C、ApoB水平呈负相关。结论:绝经后妇女CHD患者血脂异常与性激素下降密切相关,且共同参与CHD发生、发展。

Study on the correlations between sex hormones and lipid metabolism in the postmenopausal women with coronary heart disease

Objective: To investigate the correlations between serum sex hormones and lipid metabolism in postmenopausal women with coronary heart disease(CHD).Methods:58 cases of postmenopausal women with CHD were taken as the observation group,58 postmenopausal healthy women were taken as control group.The sex hormones(serum estradiol(E2),progesterone(P),testosterone(T),prolactin(PRL),luteinizing hormone(LH),follicle-stimulating hormone(FSH),E/T) and lipid metabolism(total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),high-density lipoprotein cholesterol(HDL-C),apolipoprotein B(ApoB),HDL-C/LDL-C,HDL-C/TC) related indicators were measured.Results:The levels of E2,hdl-c,E/T,HDL-C/LDL-c and HDL-C/TC in the observation group were lower than those in control group;While the levels of TC,TG,LDL-C and ApoB were higher than those in control group.The difference was statistically significant(P<0.01 or P<0.05).And on the multiple regression analysis,E2,E/T were negatively correlated with TC,TG,LDL-C and ApoB in the observation group.Conclusion: Lipid metabolism in postmenopausal women was closely related to serum sex hormones drop.They both impacted the evolution of CHD.