| MMP-9在大鼠局灶性脑缺血UK溶栓引起的再灌注损伤及出血性转化中的作用 |
| |
| 引用本文： | 王桂花,于国平,徐道华,张树平,陈晓建,杨凤兰,初芳,陈长兴,巩爱菊.MMP-9在大鼠局灶性脑缺血UK溶栓引起的再灌注损伤及出血性转化中的作用[J].中国医院药学杂志,2010(2). |
| |
| 作者姓名： | 王桂花 于国平 徐道华 张树平 陈晓建 杨凤兰 初芳 陈长兴 巩爱菊 |
| |
| 作者单位： | 烟台海港医院;烟台毓璜顶医院;滨州医学院烟台校区药理教研室; |
| |
| 基金项目： | 烟台市科学技术发展计划项目(编号:2007142) |
| |
| 摘 要： | 目的:探讨基质金属蛋白酶-9(matrix metalloproteinase-9,MMP-9)在大鼠局灶性脑缺血应用尿激酶(urokinase,UK)溶栓引起的再灌注损伤及出血性转化中的作用。方法:将实验动物随机分成UK溶栓组和线栓法缺血再灌注组。分别用免疫组织化学方法分析2组缺血后24h MMP-9的表达。结果:缺血后24h2组均有MMP-9的表达,但是UK溶栓组表达的程度明显高于线栓法缺血再灌注组。结论:UK溶栓法相较于机械法再灌注在MMP-9表达方面有明显的不同,UK溶栓组MMP-9表达明显上调。
|
| 关 键 词： | 脑缺血 基质金属蛋白酶 免疫组织化学 |
Effect of MMP-9 in UK thrombolysis-associated cerebral ischemia-reperfusion injury and hemorrhagic transformation after focal cerebral ischemia in rats |
| |
| WANG Gui-hua,YU Guo-ping,XU Dao-hua,ZHANG Shu-ping,CHEN Xiao-jian,YANG Feng-lan,CHU Fang,CHEN Chang-xing,GONG Ai-ju.Effect of MMP-9 in UK thrombolysis-associated cerebral ischemia-reperfusion injury and hemorrhagic transformation after focal cerebral ischemia in rats[J].Chinese Journal of Hospital Pharmacy,2010(2). |
| |
| Authors: | WANG Gui-hua YU Guo-ping XU Dao-hua ZHANG Shu-ping CHEN Xiao-jian YANG Feng-lan CHU Fang CHEN Chang-xing GONG Ai-ju |
| |
| Institution: | WANG Gui-hua1,YU Guo-ping2,XU Dao-hua1,ZHANG Shu-ping3,CHEN Xiao-jian1,YANG Feng-lan1,CHU Fang1,CHEN Chang-xing1,GONG Ai-ju1(1.Yantai Harbour Hospital,Sh,ong Yantai 264002,China,2.Yantai Yuhuangding Hospital,Sh,ong Yantai 264000,3.Department of Pharmacology,Binzhou Medical University,Sh,ong Binzhou 264003,China) |
| |
| Abstract: | OBJECTIVE To investigate the action of matrix metalloproteinase-9 in urokinase(UK)thrombolysis-associated cerebral ischemia-reperfusion injury and hemorrhagic transformation after focal cerebral ischemia in rats.METHODS Two groups of rats were studied:(1)rats that received UK after ischemia;(2)rats were subjected to focal ischemia using a mechanical method of middle cerebral arterial occlusion and offered mechanical reperfusion 2 hours after ischemia,then they received saline.The expression of matrix metall... |
| |
| Keywords: | cerebral ischemia matrix metalloproteinases immunohistochemistry |
| 本文献已被 CNKI 等数据库收录！ |
|
