Maurocalcine as a Non Toxic Drug Carrier Overcomes Doxorubicin Resistance in the Cancer Cell Line MDA-MB 231 |
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Authors: | Sonia Aroui Narendra Ram Florence Appaix Michel Ronjat Abderraouf Kenani Fabienne Pirollet Michel De Waard |
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Institution: | (1) INSERM, U836, Calcium Channels, Functions and Pathologies, BP 170, Grenoble Cedex 9, 38042, France;(2) Université Joseph Fourier, Institut des Neurosciences, BP 170, Grenoble Cedex 9, 38042, France;(3) UR09-09, Molecular Mechanisms and Pathologies, Faculté de Médecine de Monastir, 5019 Monastir, Tunisia |
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Abstract: | Purpose The aim of this study is to overcome tumour cell resistance that generally develops after administration of commonly used
anti-cancer drugs, such as doxorubicin.
Methods Recently, cell penetrating peptides have been used for their ability to deliver non-permeant compounds into cells. One such
cell penetrating peptide, maurocalcine, has been isolated from the venom of a Tunisian scorpion. Herein, we report the effects
of doxorubicin covalently coupled to an analogue of maurocalcine on drug-sensitive or drug-resistant cell lines MCF7 and MDA-MB
231.
Results We demonstrated the in vitro anti-tumoral efficacy of the doxorubicin maurocalcine conjugate. On a doxorubicin-sensitive cancer cell line, the maurocalcine-conjugated
form appears slightly less efficient than doxorubicin itself. On the contrary, on a doxorubicin-resistant cancer cell line,
doxorubicin coupling allows to overcome the drug resistance. This strategy can be generalized to other cell penetrating peptides
since Tat and penetratin show similar effects.
Conclusion We conclude that coupling anti-tumoral drugs to cell penetrating peptides represent a valuable strategy to overcome drug resistance.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. |
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Keywords: | cell-penetrating peptide doxorubicin drug delivery systems drug resistance maurocalcine |
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