| 国产罗红霉素胶囊和片剂的药物动力学和生物利用度比较 |
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| 引用本文： | 李珍,沈意翔,石晶.国产罗红霉素胶囊和片剂的药物动力学和生物利用度比较[J].中国药房,2000,11(1):31-33. |
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| 作者姓名： | 李珍 沈意翔 石晶 |
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| 作者单位： | ：李珍(上海长海医院临床药理研究室，上海市 200433);沈意翔(上海长海医院临床药理研究室，上海市 200433);石晶(上海长海医院临床药理研究室，上海市 200433);王卓(上海长海医院临床药理研究室，上海市 200433);范国荣(上海长海医院临床药理研究室，上海市 200433) |
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| 摘 要： | 目的：比较罗红霉素胶囊和片剂的生物利用度和药物动力学。方法：８ 名健康志愿者单剂量口服３００ｍ ｇ 罗红霉素胶囊和片剂，微生物法测定血药浓度。结果：罗红霉素胶囊和片剂的血药浓度－ 时间曲线符合二室模型，Ｃｍ ａｘ 分别为（１０－１４ ±１－６６） 和（１０－０２ ±１－８４）μｇ／ ｍｌ ；Ｔｍ ａｘ 分别为（１－４４ ±０－３２） 和（１－３１ ±０－２６）ｈ ；ＡＵＣ 分别为（７９－８７ ±１６－２２） 和（７３－８６ ±１３－４６）ｈ／（μｇ ·ｍｌ） 。结论：两种制剂药物动力学参数无显著性差异，罗红霉素胶囊和片剂具有生物等效性，胶囊相对于片剂的生物利用度为（１０９ ±１５） ％ 。
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| 关 键 词： | 罗红霉素 药物动力学 生物利用度 微生物法 |
| 文章编号： | 1001－0408（2000）01－0031－03 |
| 修稿时间： | 1999－03－25 |
Comparison of
Pharmacokinetics and Bioavailability of Roxithromycin Between Domestic Capsule and Tablet
in Healthy Subjects |
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| LI Zhen,SHEN Yixiang,SHI Jing,WANG
Zhou,FAN Guorong,HU Jinghong.Comparison of
Pharmacokinetics and Bioavailability of Roxithromycin Between Domestic Capsule and Tablet
in Healthy Subjects[J].China Pharmacy,2000,11(1):31-33. |
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| Authors: | LI Zhen SHEN Yixiang SHI Jing WANG
Zhou FAN Guorong HU Jinghong |
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| Institution: | LI Zhen,SHEN Yixiang,SHI Jing,WANG
Zhou,FAN Guorong,HU Jinghong;
(Dept.of Pharmacy,Changhai Hospital,Second Military Medical University,Shanghai
200433) |
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| Abstract: | OBJECTIVE:To compare the pharmacokinetics and bioavailability of roxithromycin (Rox) between capsule and tablet.METHODS:Eight healthy volunteers were given two preparations with a single oral dose of 300 mg in a randomized crossover study.Serum concentrations of Rox were measured by bioassay.RESULTS:The concentration-time curves of capsule and tablet fitted to a two-compartment open model.Cmax reached at (10 14±1 66) and (10 02±1 84)μg/ml,Tmax at (1 44±0 32) and (1 31±0 26)h,and AUC were (79 87±16 22) and (73 86±13 46)h/(μg·ml),respectively.CONCLUSIONS:The pharmacokinetic parameters showed no significant difference between two products.Both formulations are in bioequivalence.The relative bioavailability of capsule to tablet is (109±15)%. |
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| Keywords: | roxithromycin pharmacokinetics bioavailability bioassay |
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