电针刺激对大鼠孤束核內P物质含量的影响

<正> 文献中关于孤束核的形态及生理功能有很多报导,已知孤束核不仅和脑内很多核内及脊髓有着广泛联系,而且近年来发现孤束核内存在着多种神经递质,特别是存在着一些与痛疼有关的神经递质,如P物质(SP)、脑啡肽、5-羟色胺等。因此关于孤束核的功能,除作为内脏活动中枢外,它

EFFECT OF ELECTROACUPUNCTURE ON THE CONTENTS OF SUBSTANCE P IN THE NUCLEUS OF THE SOLITARY TRACT IN RATS

Six pairs of rats were used in the experiment. The sciatic nerve was stimulated in one of every pair with the electric needle. Then the substance P (SP-like immunoreactive nerve fibers in the nucleus of the solitary tract (NST) were showed with immunohistochmical technique (ABC METHOD)。The other of every pair was as the control. All experiemental procedures were the same as the electroacupuncture group except that the sciatic nerve wasn't stimulated. The contents of SP of NST(at the area postrema segment) of both the electroacupuncture and the control were measured with the micro-spectroscopic image analyser. The results obtained were as follows: 1. The distribution positions of SP-like immunoreactive nerve fibers in the electroacupuncture group were the same as in the control group, That is, SP-like immunoreactive nerve fibers distributed from the candal part to the rostral part in NST. 2. The contents and the area of SP-like immunoreactive nerve fibers. of the electroacupuncture were more than the control. There was a significant difference between the two groups. The results mentioned above suggested that the role of NST is involed in the acupuncture analgesia.