| 高龄对男性生育力的影响 |
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| 引用本文： | Jason,R,Kovac Josephine,Addai Ryan,P,Smith Robert,M,Coward Dolores,J,Lamb Larry,I,Lipshultz. 高龄对男性生育力的影响[J]. Asian journal of andrology, 2013, 15(6): 723-728,I0005. DOI: 10.1038/aja.2013.92 |
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| 作者姓名： | Jason R Kovac Josephine Addai Ryan P Smith Robert M Coward Dolores J Lamb Larry I Lipshultz |
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| 作者单位： | Scott Department of Urology, Department of Molecular and Cellular Biology, The Center for Reproductive Medicine, Baylor College of Medicine, Houston, TX 77030, USA |
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| 基金项目： | JRK is supported by a Male Reproductive Health Research （MRHR） Career Development Physician-Scientist Award （ K 12, HD073917-01） from the Eunice Kennedy Shriver National Institute of Child Health and Human Development （NICHD） Program awarded to DJL. DJL is supported by NIH grants P01HD36289 from the Eunice Kennedy Shriver NICHD and 1 R01DK078121 from the National Institute of Kidney and Digestive Diseases. |
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| 摘 要： | 在过去的几十年里，现代社会的压力和期望使得育龄夫妇生育年龄总体推迟。已知女性在临近40岁时卵母细胞的产生将会明显减少，而高龄对男性精子生成能力的影响还知之甚少。男性生育年龄无明确限制，因而高龄对男性生育能力的影响还不完全清楚。本文将就目前已知的高龄对男性精子质量、生育能力和子代健康的影响进行综述，希望能在医生就男性推迟生育及高龄相关的风险咨询时起到一定的指导作用。
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| 关 键 词： | 男性不育 老年男性 父亲年龄 生育结局 |
| 收稿时间： | 2013-02-27 |
The effects of advanced paternal age on fertility |
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| Jason R Kovac,Josephine Addai,Ryan P Smith,Robert M Coward,Dolores J Lamb,Larry I LipshultzScott. The effects of advanced paternal age on fertility[J]. Asian journal of andrology, 2013, 15(6): 723-728,I0005. DOI: 10.1038/aja.2013.92 |
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| Authors: | Jason R Kovac Josephine Addai Ryan P Smith Robert M Coward Dolores J Lamb Larry I LipshultzScott |
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| Affiliation: | Jason R Kovac, Josephine Addai, Ryan P Smith, Robert M Coward, Dolores J Lamb , Larry I Lipshultz(Scott Department of Urology, Department of Molecular and Cellular Biology, The Center for Reproductive Medicine, Baylor College of Medicine, Houston, TX 77030, USA) |
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| Abstract: | Modern societal pressures and expectations over the past several decades have resulted in the tendency for couples to delay conception. While women experience a notable decrease in oocyte production in their late thirties, the effect of age on spermatogenesis is less well described. While there are no known limits to the age at which men can father children, the effects of advanced paternal age are incompletely understood. This review summarizes the current state of knowledge regarding advanced paternal age and its implications on semen quality, reproductive success and offspring health. This review will serve as a guide to physicians in counseling men about the decision to delay paternity and the risks involved with conception later in life. |
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| Keywords: | aging male fertility outcomes male infertility paternal age |
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