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| 正交试验法筛选石杉碱甲骨架片处方的研究 | |
| 引用本文： | 唐宇,贺福元,周伟,刘姹,杨大坚.正交试验法筛选石杉碱甲骨架片处方的研究[J].中南药学,2009,7(3):174-176. |
| 作者姓名： | 唐宇 贺福元 周伟 刘姹 杨大坚 |
| 作者单位： | 1. 深圳市中药药学及分子药理学研究重点实验室暨香港理工大学现代中药研究所,广东,深圳,518057;湖南中医药大学药学院,长沙,410208 2. 湖南中医药大学药学院,长沙,410208;中南大学临床药理研究所,长沙,410007 3. 深圳市中药药学及分子药理学研究重点实验室暨香港理工大学现代中药研究所,广东,深圳,518057 |
| 摘 要： | 目的优化石杉碱甲骨架片的处方。方法以石杉碱甲骨架片的硬度、体外累积释放度为指标，采用3因素3水平正交设计法优化石杉碱甲骨架片的处方。结果优化所得处方HPMCK15M用量为48％，PVPP用量为6％，CMCNa用量为10％，硬度范围合适，體外溶出度符合缓释制剂要求。结论该优化所得的石杉碱甲骨架片处方可行，合理稳定。 |
| 关 键 词： | 正交试验 石杉碱甲 骨架片 缓释制剂 |
Optimization of formulation of Huperzine-A matrix tablets by orthogonal design |
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| TANG Yu,HE Fu-yuan,ZHOU Wei,LIU Cha,YANG Da-jian.Optimization of formulation of Huperzine-A matrix tablets by orthogonal design[J].Central South Pharmacy,2009,7(3):174-176. | |
| Authors: | TANG Yu HE Fu-yuan ZHOU Wei LIU Cha YANG Da-jian |
| Institution: | 1. Shengzhen State Key Laboratory of China Medicine and Molecular Pharmacology ＆ Hongkong Polytechnic University Institute of Modern Medicine, Shenzhen 518507; 2. College of Pharmaceutics , Hunan University of Traditional Chinese Medicine. Changsha 410208; 3. Institute of Clinical Pharmacology, Central South University, Changsha 410007) |
| Abstract: | Objective To optimize the formulation of Huperzine -A matrix tablets （HA-MT） . Methods According to the orthogonal design method with 3 factors and 3 levels, the formulation was optimized using hardness and cumulative release as evaluation parameters. Results The optimum formula was as follows： HPMCK15M （48%）, PVPP （6%）, CMCNa （10 %）. The hardness was proper and the cumulative release fulfilled the requirement of sustained-release dosage form design. Conclusion The formulation of matrix tablets is feasible and stable. |
| Keywords: | orthogonal design Huperzine-A matrix-tablet sustained-release |
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