| 缺血预处理对大鼠肝脏缺血再灌注损伤的保护作用 |
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| 引用本文： | 金建光,孙君军,解刚强,刘伟峰. 缺血预处理对大鼠肝脏缺血再灌注损伤的保护作用[J]. 河南科技大学学报(医学版), 2008, 26(2) |
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| 作者姓名： | 金建光 孙君军 解刚强 刘伟峰 |
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| 作者单位： | 河南科技大学第一附属医院,河南洛阳,471003;河南科技大学第一附属医院,河南洛阳,471003;河南科技大学第一附属医院,河南洛阳,471003;河南科技大学第一附属医院,河南洛阳,471003 |
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| 摘 要： | 目的 探讨缺血预处理(IPC)对肝脏缺血再灌注(I/R)损伤中细胞凋亡和Fas蛋白表达的影响.方法 60只SD大鼠随机分成正常对照组(N组)、缺血再灌注对照组(I/R组)、缺血预处理组(IPC组).比较各组血清AST、ALT和LDH水平,肝组织中凋亡细胞及细胞凋亡指数,肝组织Fas蛋白的表达情况.结果 IP组血清AST、ALT和LDH水平、细胞凋亡指数、Fas蛋白表达低于I/R组.IPC组血清ALT水平高于N组.结论 缺血预处理对肝脏缺血再灌注损伤有保护作用,可能与抑制Fas蛋白高表达、减少细胞凋亡有关.
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| 关 键 词： | 缺血预处理 细胞凋亡 Fas蛋白 |
Effects of Ischemic Preconditioning in Rat Liver Ischemic-reperfusion Injury |
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| JIN Jian-guang,SUN Jun-jun,XIE Gang-qiang,et al. Effects of Ischemic Preconditioning in Rat Liver Ischemic-reperfusion Injury[J]. Journal of Henan University of Science & Technology:Medical Science, 2008, 26(2) |
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| Authors: | JIN Jian-guang SUN Jun-jun XIE Gang-qiang et al |
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| Affiliation: | JIN Jian-guang,SUN Jun-jun,XIE Gang-qiang,et al(First Affiliated Hospital,Henan University of Science , Technology,Luoyang 471003,China) |
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| Abstract: | Objective To study effects of ischemic preconditioning(IPC) on cell apoptosis and expression of Fas protein in rats liver ischemic-reperfusion(I/R) injury. Methods 60 rats were randomized into the normal control group(N group),I/R group and IPC group.AST,ALT and LDH activities contents in serum,TUNEL cells and expression of Fas protein in liver tissue were determined. Results The values of AST,ALT and LDH were lower in IPC group than those in I/R group.Apoptosis phenomenon and expression of Fas protein were... |
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| Keywords: | ischemic-preconditioning cell apoptosis Fas protein |
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