Bmi-1在宫颈癌组织中的表达及相关性研究 |
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引用本文: | 高巧玲 吕新全 李惠翔 Qiao-ling L[U] Xin-quan Hui-xiang. Bmi-1在宫颈癌组织中的表达及相关性研究[J]. 中原医刊, 2010, 0(17) |
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作者姓名: | 高巧玲 吕新全 李惠翔 Qiao-ling L[U] Xin-quan Hui-xiang |
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摘 要: | 目的 检测不同宫颈病变中Bmi-1的表达,探讨其与宫颈癌各临床病理因素的关系及意义.方法 以宫颈癌、慢性宫颈炎组织为材料,采用免疫组化染色法检测Bmi-1蛋白表达水平,并用原位杂交法检测Bmi-1 mRNA表达水平.结果 免疫组化结果显示,Bmi-1蛋白在宫颈癌组织中的表达明显高于慢性宫颈炎组织(P<0.05).原位杂交结果显示,宫颈癌组织的Bmi-1 mRNA表达水平明显高于慢性宫颈炎组织(P<0.05).Bmi-1的表达与宫颈癌肿瘤分级、临床分期等密切相关(P<0.05),而与患者的年龄、病理分型等无关(P>0.05).结论 Bmi-1在宫颈癌组织的表达状态与其发生发展关系密切,可作为反映宫颈癌生物学行为的有效指标之一.Abstract:Objective To investigate the expression and its clinicopathologic significance of Bmi-1 in different cervical diseases. Methods Immunocytochemistry was used to examined Bmi-1 protein expression in cervical carcinoma and chronic cervicitis tissue. The mRNA expression of Bmi-1 was examined by in situ hybridzation. Results Immunocytochemistry demonstrated that the levels of Bmi-1 protein in cervical carcinoma samples were significantly higher than those in chronic cervicitis tissues(P<0.05).In situ hybridration results shows that the levels of Bmi-1 mRNA in cervical carcinoma samples were significantly higher than those in chronic cervicitis tissues(P<0.05).Expression of Bmi-1 was correlated with tumor grading and clinical stage(P<0.05). On the other hand, it was not correlated with age or pathological type(P>0.05). Conclusions Overexpression of Bmi-1 in cervical carcinoma enhances carcinogenesis and invasion. It's possible that Bmi-1 serves as a good prognostic factor to indicate biologic behavior of cervical carcinoma.
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关 键 词: | Bmi-1蛋白 宫颈癌组织 表达水平 相关性研究 cervical carcinoma 慢性宫颈炎 protein expression prognostic factor 原位杂交法 免疫组化染色法 宫颈癌生物学行为 mRNA expression Results in situ clinical stage 临床病理因素 结果 检测 significance levels |
Expression and clinical significance of Bmi-1 oncogene in cervical carcinoma |
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Abstract: | Bmi-1 Cervical carcinoma Immunohistochemistry In situ hybridization |
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Keywords: | Bmi-1 Cervical carcinoma Immunohistochemistry In situ hybridization |
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