| 58种活血化瘀类复方中成药抗血小板聚集活性评价揭示的方剂配伍规律 |
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| 引用本文： | 孟燕芝,王志龙,苏骏成,常连赢,吕明,朱彦.58种活血化瘀类复方中成药抗血小板聚集活性评价揭示的方剂配伍规律[J].中国实验方剂学杂志,2016,22(24):187-193. |
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| 作者姓名： | 孟燕芝 王志龙 苏骏成 常连赢 吕明 朱彦 |
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| 作者单位： | 天津中医药大学, 天津市现代中药重点实验室, 天津 300193;天津国际生物医药联合研究院 中药新药研发中心, 天津 300457,天津中医药大学, 天津市现代中药重点实验室, 天津 300193;天津国际生物医药联合研究院 中药新药研发中心, 天津 300457,天津中医药大学, 天津市现代中药重点实验室, 天津 300193;天津国际生物医药联合研究院 中药新药研发中心, 天津 300457,天津中医药大学, 天津市现代中药重点实验室, 天津 300193;天津国际生物医药联合研究院 中药新药研发中心, 天津 300457,天津中医药大学, 天津市现代中药重点实验室, 天津 300193;天津国际生物医药联合研究院 中药新药研发中心, 天津 300457,天津中医药大学, 天津市现代中药重点实验室, 天津 300193;天津国际生物医药联合研究院 中药新药研发中心, 天津 300457 |
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| 基金项目： | 国家自然科学基金项目（81274128）；国家国际科技合作专项（2013DFA31620） |
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| 摘 要： | 目的:通过评价58种活血化瘀类复方中成药抗血小板聚集活性并探究其用药规律,为抗血小板现代中药的研发提供一定的实验依据。方法:使用高通量微孔板比浊法检测药物对由二磷酸腺苷(ADP),凝血酶诱导的血小板聚集反应的抑制作用。结果:有41种活血化瘀类复方中成药能不同程度(药物血小板抑制聚集率达30%~98%)的拮抗ADP和凝血酶诱导的血小板聚集,其中有18种药物对诱导剂具有选择性。受试药物中,抗血小板聚集活性较高的复方多含有丹参、川芎、红花、三七、冰片等药味。活血化瘀类复方中成药多配伍补虚药、开窍药、止血药发挥其抗血小板聚集的作用。结论:活血化瘀类复方中成药可通过抗ADP和抗凝血酶的途径发挥抗血小板聚集作用,复方中配伍"理气"、"补气"、"开窍"等功效的药味或可增强其抗血小板聚集活性。
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| 关 键 词： | 活血化瘀 复方中成药 抗血小板聚集 配伍规律 |
| 收稿时间： | 2016/1/27 0:00:00 |
Evaluation of Anti-platelet Aggregation Activity and Compatibility Patterns of 58 Kinds of Compound Traditional Chinese Medicines for Promoting Blood Circulation and Removing Blood Stasis |
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| MENG Yan-zhi,WANG Zhi-long,SU Jun-cheng,CHANG Lian-ying,LYU Ming and ZHU Yan.Evaluation of Anti-platelet Aggregation Activity and Compatibility Patterns of 58 Kinds of Compound Traditional Chinese Medicines for Promoting Blood Circulation and Removing Blood Stasis[J].China Journal of Experimental Traditional Medical Formulae,2016,22(24):187-193. |
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| Authors: | MENG Yan-zhi WANG Zhi-long SU Jun-cheng CHANG Lian-ying LYU Ming and ZHU Yan |
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| Institution: | Tianjin Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Research and Development Center of Chinese Medicine, Tianjin International Joint Academy of Biomedicine, Tianjin 300457, China,Tianjin Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Research and Development Center of Chinese Medicine, Tianjin International Joint Academy of Biomedicine, Tianjin 300457, China,Tianjin Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Research and Development Center of Chinese Medicine, Tianjin International Joint Academy of Biomedicine, Tianjin 300457, China,Tianjin Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Research and Development Center of Chinese Medicine, Tianjin International Joint Academy of Biomedicine, Tianjin 300457, China,Tianjin Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Research and Development Center of Chinese Medicine, Tianjin International Joint Academy of Biomedicine, Tianjin 300457, China and Tianjin Key Laboratory of Modern Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin 300193, China;Research and Development Center of Chinese Medicine, Tianjin International Joint Academy of Biomedicine, Tianjin 300457, China |
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| Abstract: | |
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| Keywords: | promoting blood circulation and removing blood stasis Chinese patent medicine anti-platelet aggregation compatibility law |
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