早期微创颅内血肿清除术对脑出血患者IL-17、MMP-9水平的影响

目的 比较早期微创颅内血肿清除术对高压性脑出血（HCH）患者IL-17、MMP-9水平的影响,探讨IL-17、MMP-9在脑出血病程进展和恢复中的意义.方法 对我院收治的58例HCH患者分别行早期微创颅内血肿清除术和常规开颅手术,并利用ELISA方法检测术前、发病后48 h、7d、14d的血清IL-17、MMP-9水平,分析不同术式对IL-17、MMP-9水平的影响.结果 两组患者IL-17、MMP-9水平随疾病进展在术后48 h达峰值,随后分别开始下降,微创组IL-17、MMP-9下降速度明显比手术组更快（P＜0.05）.微创组治疗后7、14d的CSS评分显著低于手术组（P＜0.05）.手术前后IL-17表达与CSS评分、CRP水平正相关.结论 早期微创颅内血肿清除术治疗的临床疗效优于常规开颅手术,可显著降低IL-17、MMP-9、CRP等炎症因子水平.IL-17与CSS评分、CRP具有明显相关性,可作为脑出血术后恢复较好的生物学评估指标.

Influence of the Serum IL-17 and MMP-9 Levels in Patients with Hypertensive Cerebral Hemorrhage after Early Minimally Invasive Hematoma Aspiration

Objective To compare the influence of serum IL-17 and MMP-9 levels in hypertensive cerebral hemorrhage （HCH） patients after early minimally invasive hematoma aspiration after traditional surgical operation. To explore the effects of IL-17 and MMP-9 in the progression and recovery of the HCH patients. Methods 58 patients with HCH were randomly divided into early minimally invasive hematoma aspiration and traditional surgical operation groups. ELISA methods were used to measure the serum IL-17 and MMP-9 levels before opration, 48 hours after onset, and after 7 days and 14 days. The influence of serum IL-17 and MMP-9 levels was analyzed after different operations. Results The serum IL-17 and MMP-9 levels were elevated and achieved the peak after 48 hours in both groups, then the IL-17 and MMP-9 levels began to decline respectively, the decrease of IL-17 and MMP-9 levels in minimally invasive group was obviously faster than controls （P〈0.05）. The CSS scores after 7 and 14 days in the minimally invasive treatment group were significantly lower than controls （P〈0.05）. The IL-17 were positively correlated with CSS scores and CRP levels both at the preoperative and postoperative conditions. Conclusion The clinical effect of early minimally invasive hematoma treatment is superior to traditional surgical operation, it can obviously reduce the levels of IL-17, MMP-g, CRP and other inflammatory factors. IL-17 was obviously correlated with CSS scores and CRP levels, and could be a good biomark in the recovery of HCH patients.