β3肾上腺素能受体基因Trp64Arg多态性与蒙古族原发性高血压病相关性分析 |
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引用本文: | 张晓云,魏芳婧,徐力,阴淑莹. β3肾上腺素能受体基因Trp64Arg多态性与蒙古族原发性高血压病相关性分析[J]. 中西医结合心脑血管病杂志, 2012, 10(6): 658-660 |
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作者姓名: | 张晓云 魏芳婧 徐力 阴淑莹 |
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作者单位: | 内蒙古医学院附属医院,010050 |
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基金项目: | 内蒙古自然科学基金资助项目(No.20080404ms1123) |
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摘 要: | 目的检测蒙古族原发性高血压人群中β3肾上腺素能受体基因Trp64Arg多态性,探讨其与蒙古族人群原发性高血压病(EH)和其他心血管病危险因素的关系。方法应用PCR技术检测原发性高血压病患者102例,健康体检者93例。比较两组Trp64Arg突变基因型和临床特征。结果高血压病组与对照组β3-AR基因突变频率两者差异无统计学意义(P>0.05),基因Trp64Arg突变者的体质量指数显著高于正常基因型(P<0.05),突变者在三酰甘油、血糖、胰岛素、尿酸方面差异有统计学意义(P<0.05)。结论 Trp64Arg基因突变可能不是蒙古族原发性高血压病发生的决定因素,但该基因变异可能与肥胖、脂代谢、糖代谢等危险因素有关。
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关 键 词: | β3肾上腺素能受体 原发性高血压 基因突变 |
Association of Beta 3 Adrenergic Receptor Gene Polymorphism and Essential Hypertension in Mongolian Population |
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Affiliation: | Zhang Xiaoyun,Wei Fangjin,Xu Li,et al // The Affiliated Hospital,Inner Mongolia Medical College(Hohhot 010050) |
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Abstract: | Objective To investigate the association of beta 3 adrenergic receptor(β3AR)gene Trp64Arg polymorphism and essential hypertension(EH) in Mongolian population.Methods A total 207 Mongolian subjects including 102 patients with EH and 93 healthy controls were enrolled in the study.Polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP) and allele-specific(AS)-PCR assays were used to identify Trp64Arg genotypes.The genotypes and related clinical features were compared.Results The Mutation frequency of Trp64Arg in both groups were 33% and 33%,respectively(P>0.05).In the patients group,body mass index(BMI)in patients with gene Trp64Arg mutation were significantly higher than that in patients with normal genotype(P<0.05).Triglycerides,glucose,insulin,uric acid were significantly different between the two groups(P<0.05).Conclusion Trp64Arg mutation may not be the determinants of the occurrence of hypertension.However,the gene mutation may be related to obesity,lipid metabolism,glucose metabolism and other risk factors. |
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Keywords: | beta 3 adrenergic receptor essential hypertension gene mutation |
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