β3肾上腺素能受体基因Trp64Arg多态性与蒙古族原发性高血压病相关性分析

目的检测蒙古族原发性高血压人群中β3肾上腺素能受体基因Trp64Arg多态性,探讨其与蒙古族人群原发性高血压病(EH)和其他心血管病危险因素的关系。方法应用PCR技术检测原发性高血压病患者102例,健康体检者93例。比较两组Trp64Arg突变基因型和临床特征。结果高血压病组与对照组β3-AR基因突变频率两者差异无统计学意义(P>0.05),基因Trp64Arg突变者的体质量指数显著高于正常基因型(P<0.05),突变者在三酰甘油、血糖、胰岛素、尿酸方面差异有统计学意义(P<0.05)。结论 Trp64Arg基因突变可能不是蒙古族原发性高血压病发生的决定因素,但该基因变异可能与肥胖、脂代谢、糖代谢等危险因素有关。

Association of Beta 3 Adrenergic Receptor Gene Polymorphism and Essential Hypertension in Mongolian Population

Objective To investigate the association of beta 3 adrenergic receptor（β₃AR）gene Trp64Arg polymorphism and essential hypertension（EH） in Mongolian population.Methods A total 207 Mongolian subjects including 102 patients with EH and 93 healthy controls were enrolled in the study.Polymerase chain reaction-restriction fragment length polymorphism（PCR-RFLP） and allele-specific（AS）-PCR assays were used to identify Trp64Arg genotypes.The genotypes and related clinical features were compared.Results The Mutation frequency of Trp64Arg in both groups were 33% and 33%,respectively（P>0.05）.In the patients group,body mass index（BMI）in patients with gene Trp64Arg mutation were significantly higher than that in patients with normal genotype（P<0.05）.Triglycerides,glucose,insulin,uric acid were significantly different between the two groups（P<0.05）.Conclusion Trp64Arg mutation may not be the determinants of the occurrence of hypertension.However,the gene mutation may be related to obesity,lipid metabolism,glucose metabolism and other risk factors.