卷曲霉素、莫西沙星、利福布丁、丙硫异烟胺、吡嗪酰胺、阿莫西林／克拉维酸联合化疗耐多药结核病近期疗效观察

目的评价卷曲霉素、莫西沙星、利福布丁、丙硫异烟胺、吡嗪酰胺、阿莫西林／克拉维酸联合化疗方案治疗耐多药结核病（MDR-TB）的近期疗效。方法将34例MDR—TB患者分为治疗组和对照组，治疗组18例采用卷曲霉素、莫西沙星、利福布丁、丙硫异烟胺、吡嗪酰胺、阿莫西林／克拉维酸联合化疗方案，对照组16例采用阿米卡星、左氧氟沙星、对氨基水杨酸异烟肼、丙硫异烟胺、吡嗪酰胺、阿莫西林／克拉维酸联合化疗方案。结果经过6个月的治疗，治疗组痰茵阴转率为88．8％、病灶吸收率为83．3％、症状改善率为87．5％，对照组痰菌阴转率为56．3％、病灶吸收率为56．2％、症状改善率为50．0％，治疗组临床疗效优于对照组，差异有统计学意义（P〈0．05）。结论卷曲霉素、莫西沙星、利福布丁、丙硫异烟胺、吡嗪酰胺、阿莫西林／克拉维酸联合化疗方案治疗MDR-TB疗效优于阿米卡星、左氧氟沙星、对氨基水杨酸异烟肼、丙硫异烟胺、吡嗪酰胺、阿莫西林／克拉维酸联合化疗方案。

Capreomycin,moxifloxacin, lifubuding,sodium sulfur effect of ionized,pyrazinamide, and amoxicillin/clavulanate in the treatment of multidrug-resistant tuberculosis efficacy

Objective Evaluation of capreomycin, moxifloxacin, lifubuding, sodium sulfur effect of ionized, pyrazinamide, and amoxicillin/ clavulanate in the treatment effect of multidrug-resistant tuberculosis. Methods 34 cases of multidrug-resistant pulmonary tuberculosis patients were randomly assigned to treatment and control groups, 2 groups to different chemotherapy regimens. Results After 6 months of treatment,go to treatment sputum and yin88.8%, absorption of lesion 83.3 %, symptoms improve 87.5 %. Sputum negative turn of the control groups 56.3 %, absorption of lesion 56.2, symptoms improve 50. 0%. Treatment groups significantly better than the control group, the difference statistically significant （P0.05）. Conclusion Capreomycin,and moxifloxacin,lifubuding combined with sulfur effect of ionized,pyrazinamide,and amoxicillin/ clavulanic acid alizarin joint treatment of multidrug-resistant tuberculosis is superior to offloading,left, and para amino salicylate isoniazid combined with sulfur effect of ionized, pyrazinamide,and amoxicillin/elavulanic acid treatment for multidrug-resistant tuberculosis.