宫颈癌的DSA表现与血清VEGF表达的相关性研究

目的 探讨宫颈癌患者宫颈癌的数字减影血管造影(digital subtraction angiography,DSA)征象与血清血管内皮生长因子(vascular endothelial growth factor,VEGF)表达的相关性.方法 收集经临床确诊的40例宫颈癌患者介入手术前的影像学检查资料,介入治疗时均行DSA造影检查.同时抽取患者静脉血并分离血清后,应用酶联免疫吸附法(enzyme-linked immunosorbent assay,ELISA)定量检测血清中的VEGF含量.另检测40例正常女性体检者血清中VEGF的含量作为对照.结果 (1)宫颈癌组血清VEGF水平明显高于正常组(P＜0.01);临床分期不同,VEGF含量不同,宫颈癌VEGF水平Ⅲ期、Ⅳ期高于Ⅱ期宫颈癌VEGF水平(P＜0.05).(2)宫颈癌在DSA上肿瘤染色程度与血清VEGF水平呈明显相关性,血清VEGF水平高者肿瘤的血供增加,染色程度增高.结论宫颈癌DSA表现与血清VEGF表达呈正相关.

Study on the Correlation between the Appearances of DSA and Serum VEGF Expression in Cervical Cancer

Objective To study the correlation between ths DSA manifestations and expression of serum VEGF in the patients with cervical cancer.Methods Imaging data of 40 cases with cervical cancer confirmed by clinic were collected,and DSA were performed during interventional therapy in all cases,and the serum VEGF was detected by enzyme-linked immunosorbent assay(ELISA)which was compared with that in 40 healthy women as contrast.Results(1)Serum VEGF level in the patients with cervical cancer was significantly higher than that in control group(P＜0.01),and the serum VEGF level was significantly higher in Ⅲ and Ⅳ stage of cervical cancer than that in Ⅱ stage(P＜0.05).(2)There was positive correlation between tumor stain in DSA and the serum level of VEGF(P＜0.05).Conclusion There was positive correlation between the degree of blood supply and the serum level of VEGF.