| 两面针结晶-8镇痛作用机理的研究 |
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| 引用本文： | 洪庚辛,曾雪瑜. 两面针结晶-8镇痛作用机理的研究[J]. 药学学报, 1983, 18(3): 227-230 |
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| 作者姓名： | 洪庚辛 曾雪瑜 |
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| 作者单位： | 广西壮族自治区中医药研究所 南宁(洪庚辛)，广西壮族自治区中医药研究所 南宁(曾雪瑜) |
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| 摘 要： | 作者前文报道了两面针Zanthoxylum nitidum(Roxb.)DC.根提取物N-4及从N-4中分离出的结晶-8(分子式为C_(20)H_(18)O_6,结构待定,下简称结晶-8)的解痉镇痛作用。并证明结晶-8的解痉作用是直接作用于肠平滑肌。而镇痛作用具有中枢性,并与脑内单胺类递质有关,但与脑内吗啡受体无直接关系。本文仅就结晶-8镇痛作用与中枢某些递质的作用关系加以研究。
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| 关 键 词： | 结晶-8 利血平 1-多巴 dl-5-羟色氨酸 二乙基二硫代氨基甲酸酯 胆碱能药物 多巴胺能药物 |
| 收稿时间： | 1982-01-28 |
STUDIES ON THE MECHANISM OF ANALGESIC ACTION OF CRYSTAL-8 ISOLATED FROM ZANTHOXYLUM NITIDUM (ROXb.) DC. |
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| HONG Geng-xin and ZENG Xue-yu. STUDIES ON THE MECHANISM OF ANALGESIC ACTION OF CRYSTAL-8 ISOLATED FROM ZANTHOXYLUM NITIDUM (ROXb.) DC.[J]. Acta pharmaceutica Sinica, 1983, 18(3): 227-230 |
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| Authors: | HONG Geng-xin and ZENG Xue-yu |
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| Abstract: | Some tool-drugs, which affect transmitters in the central nervous system, were used to explore the analgesic action of crystal-8 related to cholinergic system and monoamine transmitters. The analgesic action of crystal-8 was not affected by scopolamine,physostigmine, apomorphine and haloperidol, but was antagonized by reserpine. The analgesic action of crystal-8 was potentiated by 1-dopa (50 mg/kg, ip) and dl-5-HTP (56mg/kg, ip) after intraperitoneal administration of decarboxylase inhibitor (RO-4-4602), or dopamine β-hydroxylase inhibitor DDC Therefore, the authors propose that the analgesic action of crystal-8 may be related to the level of DA and 5-HT in brain, especially DA. |
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| Keywords: | Crystal-8 1-Dopa D1-5-Hydroxytryptophan Diethyldithiocarbamate Reserpine Cholinergic drugs Dopaminergic drugs. |
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