Evidence for autonomous secretion of prolactin in some alcoholic men with cirrhosis and gynecomastia |
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Authors: | David H. Van Thiel Craig J. McClain Michael K. Elson Michael J. McMillan Roger Lester |
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Affiliation: | 1. Division of Gastroenterology, Department of Medicine, University of Pittsburgh, School of Medicine, Pittsburgh, Penn. 15261 USA;2. The Division of Gastroenterology, Veterans Administration Hospital, Minneapolis, Minn. 55417 USA;3. The Division of Endocrinology, Veterans Administration Hospital, Minneapolis, Minn. 55417 USA |
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Abstract: | Prolactin responses to provocative thyrotropin releasing hormone (TRH) stimulation were evaluated in 20 cirrhotic men with gynecomastia. Fifteen of these cirrhotic men had normal responses with a minimum doubling of the prolactin concentration above basal in response to TRH. Five had abnormal (autonomous) responses in that they failed to double their basal level or had a paradoxical decrease from basal in response to TRH. Moreover, these same five men failed to have a sleep-related increase in plasma prolactin. Three of them also failed to respond to chlorpromazine stimulation. Such abnormal responses are generally associated with the presence of a prolactin secreting pituitary tumor. Basal plasma levels of prolactin were measured in all 20 men studied. The five men who failed to respond to TRH had significantly greater basal prolactin concentrations (80.5 ± 18.7 ng/ml) than did the 15 men who responded normally (33.7 ± 4.3 ng/ml) (p < 0.01), although all 20 had increased prolactin levels relative to that of controls (10.8 ± 0.9 ng/ml) (both p < 0.01). |
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Keywords: | Address reprint requests to David H. Van Thiel, M.D. 1000G Scaife Hall, University of Pittsburgh, School of Medicine, Pittsburgh, Penn. 15261. |
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