| nm23基因在涎腺腺体囊性癌中的表达及其与肺转移的关系 |
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| 引用本文： | 史宏男,何荣根.nm23基因在涎腺腺体囊性癌中的表达及其与肺转移的关系[J].中华口腔医学杂志,1997,32(1):4-6. |
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| 作者姓名： | 史宏男 何荣根 |
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| 摘 要： | 为探讨肿瘤转移抑制基因ｎｍ２３与涎腺腺性囊性癌（ａｄｅｎｏｉｄｃｙｓｉｔｃｃａｒｃｉｎｏｍａ，ＡＣＣ）的关系，应用ＬＳＡＢ免疫组化染色方法，研究ｎｍ２３表达产物二磷酸核苷激酶（ｎｕｃｌｅｏｓｉｄｅｄｉｐｈｏｓｐａｔｅｋｉｎａｓｅ，ＮＤＰＫ）在ＡＣＣ中的表达，结果：ＮＤＰＫ／ｎｍ２３在ＡＣＣ中较高表达，阳性率为６４．０％（１６／２５）；其中，在肺转移者阳性率为１２．５％（１／８）无肺转移阳性率为８８
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| 关 键 词： | 涎腺肿瘤 腺样囊性癌 肺转移 nm23基因 |
nm23 expression and its correlation with lung metastasis in human salivary adenoid cystic carcinoma] |
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| H Shi,R He,W Qiu.nm23 expression and its correlation with lung metastasis in human salivary adenoid cystic carcinoma][J].Chinese Journal of Stomatology,1997,32(1):4-6. |
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| Authors: | H Shi R He W Qiu |
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| Institution: | School of Stomatology, Shanghai Second Medical University. |
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| Abstract: | The nm23 gene products, nucleoside diphosphate kinase (NDPK), expression in salivary adenoid cystic carcinoma (ACC) was evaluted by using LSAB immunohistochemical method. Of 25 cases tested, 16 (64.0%) showed positive staining, in which, higher incidence of positive staining was found in ACC without lung metastasis (88.2%, 15/17) than in that with lung metastasis (12.5%, 1/8; P < 0.01). Expression of NDPK/nm23 was correlated with the P-TNM pattern (P < 0.05), otherwise it was not correlated with pathologic types (P > 0.05). The result suggest that the nm23/NDPK may play a role in suppressing the metastatic potential in ACC. |
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