Tissue Oxygen Demand in Regulation of the Behavior of the Cells in the Vasculature |
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| Authors: | Nadezhda N Barvitenko Muhammad Aslam Jessica Filosa Elena Matteucci Mikko Nikinmaa Antonella Pantaleo Carlota Saldanha Oguz K Baskurt |
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| Institution: | 1. Russian Academy of Sciences, , Saint‐Petersburg, Russia;2. Institute of Physiology, Justus Liebig University, , Giessen, Germany;3. Department of Physiology, Georgia Health Sciences University, , Augusta, Georgia, USA;4. Department of Clinical and Experimental Medicine, University of Pisa, , Italy;5. Department of Biology, University of Turku, , Turku, Finland;6. Department of Biomedical Science, University of Sassari, , Italy;7. Institute of Biochemistry, Institute of Molecular Medicine, Faculty of Medicine University of Lisbon, , Portugal;8. Koc University School of Medicine, , Istanbul, Turkey |
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| Abstract: | The control of arteriolar diameters in microvasculature has been in the focus of studies on mechanisms matching oxygen demand and supply at the tissue level. Functionally, important vascular elements include EC, VSMC, and RBC. Integration of these different cell types into functional units aimed at matching tissue oxygen supply with tissue oxygen demand is only achieved when all these cells can respond to the signals of tissue oxygen demand. Many vasoactive agents that serve as signals of tissue oxygen demand have their receptors on all these types of cells (VSMC, EC, and RBC) implying that there can be a coordinated regulation of their behavior by the tissue oxygen demand. Such functions of RBC as oxygen carrying by Hb, rheology, and release of vasoactive agents are considered. Several common extra‐ and intracellular signaling pathways that link tissue oxygen demand with control of VSMC contractility, EC permeability, and RBC functioning are discussed. |
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| Keywords: | Microvascular blood flow tissue oxygen demand red blood cell endothelial cell vascular smooth muscle cell regulation |
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