Enzyme induction by repeated administration of tetrachlorvinphos in rats |
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Authors: | Kayoko Moroi Shizuko Ushiyama Tetsuo Satoh Tetsuro Kuga |
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Affiliation: | Department of Experimental Pharmacology, Research Institute for Chemobiodynamics, Chiba University, Narashino, Chiba, Japan |
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Abstract: | The capability of enzyme induction in male rats was studied following the administration of tetrachlorvinphos (TCVP). A single oral dose of either 250 or 1000 mg/kg caused a more marked inhibition of true (erythrocyte) ChE than of pseudo (serum) and brain ChE activities. Dose-related increases in the activities of two hepatic microsomal enzyme activities, aminopyrine demethylase and EPN (o-ethyl O-p-nitro-phenyl phenylphosphonothioate) detoxification enzyme, were observed after 10 days of successive administration of TCVP at doses of 60 and 250 mg/kg, po. The liver to body weight ratio of rats increased on the first 7 days and then decreased on Day 10. The repeated administration of TCVP induced the enzymes responsible for the metabolism of TCVP up to 7-fold in microsomes and 1.2-fold in the supernatant fraction. The results demonstrate that the repeated application of TCVP as an insecticide may decrease its toxicity by its capacity to induce metabolizing enzymes. |
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Keywords: | Present address: Department of Biochemical Pharmacology Faculty of Pharmaceutical Sciences University of Chiba Chiba Japan. Requests for reprints should be sent to Dr. T. Satoh. |
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