| 获得性纯红细胞再生障碍性贫血的细胞免疫发病机制的研究进展 |
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| 引用本文： | 代阳. 获得性纯红细胞再生障碍性贫血的细胞免疫发病机制的研究进展[J]. 中国实验血液学杂志, 2003, 11(1): 105-108 |
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| 作者姓名： | 代阳 |
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| 作者单位： | 四川大学华西医院血液科,成都,610041 |
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| 摘 要： | 纯红细胞再生障碍性贫血是以骨髓单纯红系造血衰竭或紊乱为特征的一组导质性疾病，分为先天性和获得性两类。细胞免疫介导的红系造血损伤可能是获得性纯红细胞再生障碍性贫血的主要发病机制。本就近年来关于获得性纯红细胞再生障碍性贫血的T细胞异常、T细胞亚群改变、异常T细胞的克隆性以及细胞因子在发病过程中所起的作用做一综述。
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| 关 键 词： | 纯红细胞再生障碍性贫血 细胞免疫异常 T细胞亚群 细胞因子 |
| 文章编号： | 1009-2137(2003)01-0105-04 |
| 修稿时间： | 2002-03-18 |
The Advance of Research on Pathogenesis of Acquired Pure Red Cell Aplastic Anemia Caused by Cellular Immune Abnormalities |
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| DAI Yang. The Advance of Research on Pathogenesis of Acquired Pure Red Cell Aplastic Anemia Caused by Cellular Immune Abnormalities[J]. Journal of experimental hematology, 2003, 11(1): 105-108 |
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| Authors: | DAI Yang |
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| Affiliation: | Department of Hematology, West China Hospital of Sichuan University, Chengdu 610041, China. tingliu@mail.sc.cninfo.net |
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| Abstract: | Pure red cell aplastic anemia (PRCA) is a group of heterogeneous disorders characterized by erythropoiesis failure or disorder of bone marrow function. PRCA can be classified as congenital and acquired types. The recent researches have shown that cellular immune abnormalities are main reasons to cause PRCA. This review will focus on the focus points: T lymphocytes abnormalities, change of T cell subset phenotypes, abnormality of cellular clonality,and effects of related cytokines in PRCA. |
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| Keywords: | pure red cell aplastic anemia cellular immune abnormality T cell subset cytokine |
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