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硫唑嘌呤脂质体的研制
引用本文:董亚琳,董卫华,张丽. 硫唑嘌呤脂质体的研制[J]. 中国药房, 2003, 14(12): 721-723
作者姓名:董亚琳  董卫华  张丽
作者单位:1. 西安交通大学第一医院药剂科,西安市,710061
2. 西安交通大学药学院,西安市,710061
摘    要:目的 :优选硫唑嘌呤脂质体的处方和制备工艺 ,并评价其质量。方法 :采用薄膜 -振荡分散法制备硫唑嘌呤脂质体 ,以正交试验法优选出制备硫唑嘌呤脂质体的最佳工艺条件。用滴定法测其包封率 ,显微镜法观察其形态 ,测量粒径和粒度分布。结果 :制备的脂质体的包封率达到49 19 % ,透射电子显微镜下观察脂质体为粒径均匀的球状或近球状的多室脂质体 ,小于2 4μm的粒子占78 17 %。结论 :优选得到的脂质体处方和制备工艺合理、稳定

关 键 词:硫唑嘌呤  脂质体  包封率  质量评价
文章编号:1001-0408(2003)12-0721-03
修稿时间:2003-01-20

Study on the Preparation of Azathioprine Liposomes
DONG Yalin,DONG Weihua. Study on the Preparation of Azathioprine Liposomes[J]. China Pharmacy, 2003, 14(12): 721-723
Authors:DONG Yalin  DONG Weihua
Abstract:OBJECTIVE:To optimize the formulation and preparation technic of azathioprine liposomes and evaluation the quality.METHODS:The liposomes were prepared by a film-vibration technique.The optimal formulation and preparation technic were selected by means of an orthogonal design test.The entrapment ratio of liposomes was studied by titrimetric method.The size distribution and appearance of liposomes were observed under microscope.RESULTS:The entrapment ratio of azathioprine liposomes was49.19%.The liposomes consisted of spherical or similar to spherical multilamellar vesicles with78.17%of particles in the liposomes smaller than2.4μm.CONCLUSION:The selected formulation and preparation technic of azathioprine liposomes are rational and stable.
Keywords:azathioprine  liposome  entrapment ratio  quality evaluation
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