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Autoimmunity and HIV/simian immunodeficiency virus infection: A two edged sword |
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| Authors: | Aftab A. Ansari Kovit Pattanapanyasat Lara E. Pereira |
| Affiliation: | Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, Georgia, USA and;Center of Excellence for Flow Cytometry, Division of Instruments for Research, Office for Research and Development, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand |
| Abstract: | The purpose of this review is to provide an overview of the spectrum of autoimmune responses that we have so far characterized in the simian immunodeficiency virus (SIV)-infected disease susceptible rhesus macaques, the potential role of the lymphopenic state for the generation of the autoimmune response and the important new finding that such autoimmune response in fact can serve to provide both clinical benefit and clinical disease depending on the stage of the disease and the nature of the host proteins that are recognized during this process. |
| Keywords: | autoimmunity HIV non-human primates SIV |