超敏C-反应蛋白与冠心病、心肌梗死的相关性探讨

目的探讨血清超敏C反应蛋白（hs—CRP）与冠心病（CHD）、心肌梗死（AMI）等疾病发生的关系。方法收集冠心病（CHD）患者61例、心肌梗死（AMI）患者45例作为患者组（排除同时引起的hs-CRP水平升高的其他疾病）；收集肝。肾功能、血脂、血糖、白细胞、心电图等体检指标正常的体检人员35例作为对照组。在日立7060全自动生化分析仪上应用乳胶增强免疫透射比浊法测定血清中hs-CRP的浓度和心肌酶谱，而心肌梗死组同时用免疫荧光法测定cTnI，并分析对照组与患者组、患者组治疗前后的hs-CRP水平的差异及hs—CRP与心肌酶谱、cTnI的关系。结果冠心病与心肌梗死患者的hs—CRP浓度与对照组相比明显升高，差异具有统计学意义（P〈0．01）；并且患者在治疗前后hs-CRP浓度差异有统计学意义（P〈0．01）。而且hs—CRP与心肌酶谱、心肌肌钙蛋白（cTnI）的水平呈正相关关系。结论冠心病与心肌梗死患者血清hs—CRP水平明显升高。检测hs—CRP对冠心病与心肌梗死的辅助诊断、疗效观察及预后判断具有重要价值。

Study on the correlation between hs-CRP and coronary heart disease as well as acute myocardial infarction

Objective To explore the relationship between high-sensitivity C-reactive protein (hs-CRP) and the occurrence of certain diseases such as coronary heart disease (CHD) and acute myocardial infarction (AMI).Methods Sixty-one CHD patients, 45 AMI patients (patients group, excluding high hs-CRP level diseases caused by other etiological factors) and 35 healthy controls (control group) were enrolled in the study. The serum level of hs-CRP and myocardial zymogram was measured in the Hitachi 7060 automatic analyzer by latex-enhance immunoturbidimetry for all subjects, and cTnI of AMI group was detected with immunofluorescence method at the same time. The difference of hs-CRP level was compared and analyzed between control group and patients group; control group before and after treatment. Moreover, the relationship between hs-CRP and myocardial zymogram as well as cTnI was analyzed.Results The level of hs-CRP was significantly higher in patients group than that in control group (P<0.01). There was statistical difference of hs-CRP level before and after treatment in control group (P<0.01). hs-CRP was positively correlative with myocardial zymogram and cTnI.Conclusion The serum level of hs-CRP is significantly elevated in CHD and AMI patients, indicating the measurement of hs-CRP contributes to auxiliary diagnosis, therapeutic effect observation, and prognosis evaluation.