| 洛索洛芬钠片溶出度测定及体内外相关性评价 |
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| 引用本文： | 唐黎明,陈桂良.洛索洛芬钠片溶出度测定及体内外相关性评价[J].中国医药工业杂志,2006,37(8):550-552. |
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| 作者姓名： | 唐黎明 陈桂良 |
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| 作者单位： | 上海市食品药品检验所,上海,200233 |
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| 摘 要： | 参照中国药典2005年版溶出度试验第二法，建立了UV法测定洛索洛芬钠片体外溶出度的试验方法，并用HPLC法测定洛索洛芬钠片的人体药物动力学，进行了体内外相关性的评价。结果表明洛索洛芬钠片体内外相关性良好，提示体外溶出度试验方法合理。
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| 关 键 词： | 洛索洛芬钠片 体外溶出度 体内外相关 |
| 文章编号： | 1001-8255（2006）08-0550-03 |
| 收稿时间： | 2005-11-22 |
| 修稿时间： | 2005-11-22 |
Dissolution of Loxoprofen Sodium Tablets and Evaluation of in vitro-in vivo Correlation |
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| Authors: | TANG Li-Ming CHEN Gui-Liang |
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| Institution: | Shanghai Institute for Durg Control, Shanghai 200233 |
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| Abstract: | An UV method for determination of dissolution of loxoprofen sodium tablets was established according to ChP dissolution method II. The pharmacokinetics of loxoprofen sodium tablets in human was determined by HPLC. The results showed that the relationship between dissolution in vitro and absorption in vivo was correlated, indicating the method for the dissolution test of loxoprofen sodium tablets was feasible. |
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| Keywords: | loxoprofen sodium tablets dissolution in vitro and in vivo correlation |
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