| 胃癌和胃癌前病变组织FHIT基因的杂合性丢失 |
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| 引用本文： | 刘平,游思洪,张小勇,张道富,丁小健. 胃癌和胃癌前病变组织FHIT基因的杂合性丢失[J]. 世界华人消化杂志, 2005, 13(10): 1190-1193 |
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| 作者姓名： | 刘平 游思洪 张小勇 张道富 丁小健 |
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| 作者单位： | 南京医科大学第一附属医院肿瘤科,江苏省南京市,210029;南京医科大学第一附属医院消化科,江苏省南京市,210029;南京医科大学第一附属医院中心实验室,江苏省南京市,210029 |
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| 基金项目： | 江苏省医学重点人才135工程资助项目,No．52—2001~~ |
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| 摘 要： |
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| 关 键 词： | 胃肿瘤 胃癌 癌前病变 脆性组氨酸三联体 杂合性丢失 |
| 修稿时间： | 2005-01-28 |
Heterozygosity loss of fragile histidine triad gene in gastric cancer and precancerous lesions |
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| Ping Liu,Si-Hong You,Xiao-Yong Zhang,Dao-Fu Zhang,Xiao-Jian Ding. Heterozygosity loss of fragile histidine triad gene in gastric cancer and precancerous lesions[J]. World Chinese Journal of Digestology, 2005, 13(10): 1190-1193 |
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| Authors: | Ping Liu Si-Hong You Xiao-Yong Zhang Dao-Fu Zhang Xiao-Jian Ding |
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| Affiliation: | Ping Liu,Si-Hong You,Department of Oncology,the Fust Affiliated Hospital of Najing Medical University,Nanjing 210029,Jiangsu Province,China Xiao-Yong Zhang,Dao-Fu Zhang,Department of Gastroenterology,the First Affiliated Hospital of Najing Medical University,Nanjing 210029,Jiangsu Province,China Xiao-Jian Ding,Central Laboratory,the First Affiliated Hospital of Najing Medical University,Nanjing 210029,Jiangsu Province,China |
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| Abstract: | AIM: To detect the loss of heterozygosity (LOH) of fragile histidine triad (FHIT) gene in gastric cancer and precan-cerous lesions (dysplasia and intestinal metaplasia), and to analyze its role in the carcinogenesis of gastric cancer. METHODS: The LOH at microsatellites loci D3S1234 and D3S1300 of FHIT gene were measured in samples of gastric cancer (n = 42), dysplasia (n = 44), intestinal metaplasia (n = 51) and their corresponding normal tissues by (polymerase chain reaction) PCR. RESULTS: The rates of LOH at D3S1234 locus were 32.4% (11/34), 28.6%(10/35) and 10%(4/40) in gastric cancer, dysplasia and intestinal metaplasia respectively, and the ones at D3S1300 locus were 33.3%(12/36), 32.4%(11/34) and 7.7% (3/39) respectively. The LOH rates at D3S1234 and D3S1300 loci in gastric cancer and atypical hyperpla-sia were higher than that of intestinal metaplasia (P<0.05, P<0.01 for D3S1234 and D3S1300 respectively). No significant difference of LOH rate was found between gastric cancer and dysplasia. CONCLUSION: The loss of heterozygosity of FHIT gene may be an early event in the tumorigenesis of gastric cancer. |
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| Keywords: | Stomach neoplasms Gastric cancer Precan-cerous lesion Fragile histidine triad Loss of heterozygosriy |
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