阿托伐他汀对糖尿病肾病患者抗氧化应激作用的临床观察

目的：观察阿托伐他汀对抗糖尿病肾病患者肾氧化损伤作用。方法：56例糖尿病肾病患者随即分为对照组和阿托伐他汀组。对照组给予降糖、降压等治疗，阿托伐他汀组则在对照组治疗基础上加用阿托伐他汀10mg／d，疗程共12周。检测两组患者治疗前后FBG、BUN、Scr、尿微量白蛋白以及血脂、血清SOD和MDA水平。结果：12周后两组患者FBG、BUN、Scr、尿微量白蛋白均较治疗前下降；与治疗前相比，阿托伐他汀组患者血脂水平较治疗前明显改善，同时患者血清SOD活性增，MDA含量下降，二者之间的差异具有显著性意义。结论：阿托伐他汀除具有降血脂作用外，还可改善糖尿病肾病患者的氧化应激状态。

Clinical Observation of Atorvastatin on Anti-renal Oxidative Damage of Diabetic Nephropathy

Objective：To observe the effect of atorvastatin on anti- renal oxidative damage of diabetic nephropathy （DN）. Methods： Fifteen-six patients of DN were randomly divided into control group and treatment group. The con trol group was treated with conventional therapy. Meanwhile,the other 28 patients in treatment group, on the basis of the control group,were treated by atorvastatin 30 mg once a day, with a treatment course of 12 weeks for both groups. Levels of FBG,BUN,Scr and blood lipid（TC,TG,LDL C and HDL-C）,as well as malondialdehyde（MDA）, total superoxide dismutase（ SOD） activity of serum were tested before and after treatment. Results：In all cases, the level of FBG,BUN and Scr deereased obviously after treatment for 12 weeks. However, the level of blood lipid was improved after treated by atorvastatin, The level of MDA also decreased significantly and the activity of SOD in creased significantly in the treatment group compared to the control group. Conclusion ： Atorvastatin can improved the oxidative stress in DN.