| (2S,3R)-1-二甲氨基-3-(3-甲氧基苯基)-2-甲基戊-3-醇的合成工艺研究 |
| |
| 引用本文： | 谢 应,黄淑云,李兴伟,方 玲.(2S,3R)-1-二甲氨基-3-(3-甲氧基苯基)-2-甲基戊-3-醇的合成工艺研究[J].现代药物与临床,2011,26(6):461-463. |
| |
| 作者姓名： | 谢 应 黄淑云 李兴伟 方 玲 |
| |
| 作者单位： | 谢应 (天津中医药大学,天津,300193) ； 黄淑云 (天津药物研究院化学制药研究部,天津,300193) ； 李兴伟 (天津药物研究院化学制药研究部,天津,300193) ； 方玲 (天津中医药大学,天津,300193) ； |
| |
| 摘 要： | 目的 对(2S,3R)- 1-二甲氨基-3-(3-甲氧基苯基)-2-甲基戊-3-醇合成工艺进行研究.方法 以3-戊酮为起始原料,经Mannich反应、手性拆分、Grignard反应等步骤合成(2S,3R)-1-二甲氨基-3-(3-甲氧基苯基)-2-甲基戊-3-醇,并对化学拆分进行工艺优化.结果 合成(2S,3R)-1...
|
| 关 键 词： | (2S 3R)- 1二甲氨基-3 -(3-甲氧基苯基)-2-甲基戊-3-醇 化学合成 Grignard反应 Mannich反应 手性拆分 |
Synthesis of (2S,3R)-1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol |
| |
| XIE Ying,HUANG Shu-yun,LI Xing-wei and FANG Ling.Synthesis of (2S,3R)-1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol[J].Drugs & Clinic,2011,26(6):461-463. |
| |
| Authors: | XIE Ying HUANG Shu-yun LI Xing-wei and FANG Ling |
| |
| Institution: | 1.Tianjin University of Traditional Chinese Medicine,Tianjin 300193,China 2.Centre for Chemical Pharmaceutical Research,Tianjin Institute of Pharmaceutical Research,Tianjin 300193,China |
| |
| Abstract: | Objective To study the synthetic technology of (2S,3R)-1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol. Methods 3-Pentanone was taken as the starting material, (2S,3R)-1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol was obtained after a series of chemical reactions including Mannich reaction, resolution, Grignard reaction, and so on. At the same time, the procedure of chiral resolution was optimized. Results (2S,3R)-1-dimethylamino-3-(3-methoxyphenyl)-2-methylpentan-3-ol was synthesized with an overall yield of 30.6%. Conclusion The improved procedure can increase the yield of product and reduce the waste of raw material. |
| |
| Keywords: | (2S 3R)-1-dimethylamino-3-(3-methoxyphenyl)-2methylpentan-3-ol chemical synthesis Grignard reaction Mannich reaction chiral resolution |
| 本文献已被 CNKI 等数据库收录！ |
| 点击此处可从《现代药物与临床》浏览原始摘要信息 |
| 点击此处可从《现代药物与临床》下载免费的PDF全文 |
|
